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    Klhl38 kelch-like family member 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314996, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl38provided by RGD
    Official Full Name
    kelch-like family member 38provided by RGD
    Primary source
    RGD:1564169
    See related
    EnsemblRapid:ENSRNOG00000007896 AllianceGenome:RGD:1564169
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL38 (kelch like family member 38). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 118.4), Heart (RPKM 97.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl38 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91744634..91753843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89854015..89864352, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (98187954..98197163, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene F-box protein 32 Neighboring gene uncharacterized LOC102549374 Neighboring gene uncharacterized LOC134479910 Neighboring gene annexin A13 Neighboring gene uncharacterized LOC134479911 Neighboring gene family with sequence similarity 91, member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108871

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 38
    Names
    kelch-like 38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025008.1 → NP_001020179.1  kelch-like protein 38

      See identical proteins and their annotated locations for NP_001020179.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091195
      UniProtKB/Swiss-Prot
      Q5BK60
      UniProtKB/TrEMBL
      A6HRK1
      Related
      ENSRNOP00000010484.5, ENSRNOT00000010484.7
      Conserved Domains (7) summary
      smart00612
      Location:479 → 520
      Kelch; Kelch domain
      PHA03098
      Location:48 → 498
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:372 → 416
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:24 → 128
      BTB; BTB/POZ domain
      pfam01344
      Location:509 → 559
      Kelch_1; Kelch motif
      pfam07707
      Location:136 → 237
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:280 → 320
      Kelch_6; Kelch motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      91744634..91753843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765509.3 → XP_008763731.1  kelch-like protein 38 isoform X1

      See identical proteins and their annotated locations for XP_008763731.1

      UniProtKB/Swiss-Prot
      Q5BK60
      UniProtKB/TrEMBL
      A6HRK1
      Conserved Domains (7) summary
      smart00612
      Location:479 → 520
      Kelch; Kelch domain
      PHA03098
      Location:48 → 498
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:372 → 416
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:24 → 128
      BTB; BTB/POZ domain
      pfam01344
      Location:509 → 559
      Kelch_1; Kelch motif
      pfam07707
      Location:136 → 237
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:280 → 320
      Kelch_6; Kelch motif

    2. XM_017594858.3 → XP_017450347.1  kelch-like protein 38 isoform X2

      Related
      ENSRNOP00000110776.1, ENSRNOT00000154189.1
      Conserved Domains (7) summary
      smart00612
      Location:333 → 382
      Kelch; Kelch domain
      smart00225
      Location:35 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:321 → 369
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:24 → 128
      BTB; BTB/POZ domain
      pfam01344
      Location:371 → 417
      Kelch_1; Kelch motif
      pfam07707
      Location:136 → 237
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:280 → 320
      Kelch_6; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK60.1 GenPept UniProtKB/Swiss-Prot:Q5BK60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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