Avp arginine vasopressin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Avpprovided by RGD
Official Full Name: arginine vasopressinprovided by RGD
Primary source: RGD:2184
See related: EnsemblRapid:ENSRNOG00000021229 AllianceGenome:RGD:2184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DI; VP; ADH; Vas
Summary: Enables V1A vasopressin receptor binding activity; V1B vasopressin receptor binding activity; and neuropeptide hormone activity. Involved in several processes, including grooming behavior; maternal aggressive behavior; and maternal behavior. Located in dendrite; extracellular space; and secretory granule. Is active in neuronal dense core vesicle. Used to study diabetes insipidus; hyperglycemia; portal hypertension; temporal lobe epilepsy; and type 1 diabetes mellitus. Biomarker of hypertension; neurohypophyseal diabetes insipidus; type 2 diabetes mellitus; and vascular dementia. Human ortholog(s) of this gene implicated in diabetes insipidus and neurohypophyseal diabetes insipidus. Orthologous to human AVP (arginine vasopressin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 24.5) and Testes (RPKM 3.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138246544..138248522, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117793447..117805091, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123117482..123119460, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons.
Title: Ionic mechanisms involved in arginine vasopressin-mediated excitation of auditory cortical and thalamic neurons.
Stimulatory effects of vasopressin on progesterone production and BMP signaling by ovarian granulosa cells.
Title: Stimulatory effects of vasopressin on progesterone production and BMP signaling by ovarian granulosa cells.
Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia.
Title: Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia.
Transgenic approaches to opening up new fields of vasopressin and oxytocin research.
Title: Transgenic approaches to opening up new fields of vasopressin and oxytocin research.
Conditional ablation of vasopressin-synthesizing neurons in transgenic rats.
Title: Conditional ablation of vasopressin-synthesizing neurons in transgenic rats.
Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.
Title: Paternal stress in rats increased oxytocin, oxytocin receptor, and arginine vasopressin gene expression in the male offspring amygdala with no effect on their social interaction behaviors.
Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy.
Title: Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy.
Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model.
Title: Postnatal AVP treatments prevent social deficit in adolescence of valproic acid-induced rat autism model.
Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.
Title: Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.
Interaction of Orexin A and Vasopressin in the Brain Plays a Role in Blood Pressure Regulation in WKY and SHR Rats.
Title: Interaction of Orexin A and Vasopressin in the Brain Plays a Role in Blood Pressure Regulation in WKY and SHR Rats.

Submit: New GeneRIF Correction See all GeneRIFs (157)

General gene information

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Markers

Avp (e-PCR), detects polymorphism
- UniSTS:506746

D3Mgh22 (e-PCR)
- UniSTS:240274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables V1A vasopressin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables V1A vasopressin receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables V1A vasopressin receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables V1A vasopressin receptor binding	ISO Inferred from Sequence Orthology more info
enables V1B vasopressin receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables V2 vasopressin receptor binding	TAS Traceable Author Statement more info	PubMed
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables neurohypophyseal hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of female receptivity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular pH reduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vasopressin-neurophysin 2-copeptin

Names: AVP-NPII; antidiuretic hormone; arginine vasopressin (Diabetes insipidus), same as Di (conflicting physical mapping); prepropressophysin; preprovasopressin-neurophysin; vasopressin; vasopressin-neurophysin prepropeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.