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    Stac2 SH3 and cysteine rich domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stac2provided by RGD
    Official Full Name
    SH3 and cysteine rich domain 2provided by RGD
    Primary source
    RGD:1305548
    See related
    EnsemblRapid:ENSRNOG00000004805 AllianceGenome:RGD:1305548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to be located in cytoplasmic side of plasma membrane. Orthologous to human STAC2 (SH3 and cysteine rich domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 22.3), Lung (RPKM 9.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stac2 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83528741..83544583, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83032418..83048260, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85988367..86004209, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene ARF like GTPase 5C Neighboring gene calcium voltage-gated channel auxiliary subunit beta 1 Neighboring gene ribosomal protein L19 Neighboring gene uncharacterized LOC102548674 Neighboring gene F-box and leucine-rich repeat protein 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stac Proteins Suppress Ca(2+)-Dependent Inactivation of Neuronal l-type Ca(2+) Channels. Polster A, et al. J Neurosci, 2018 Oct 24. PMID 30201773, Free PMC Article
    2. Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of Ca(V)1.1. Polster A, et al. J Gen Physiol, 2018 Apr 2. PMID 29467163, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There is a large postnatal increase in Stac2 expression in forebrain and cerebellum.
      Title: Stac Proteins Suppress Ca(2+)-Dependent Inactivation of Neuronal l-type Ca(2+) Channels.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH3 and cysteine-rich domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399483.1 → NP_001386412.1  SH3 and cysteine-rich domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JU98, D0IN10
      Related
      ENSRNOP00000069019.3, ENSRNOT00000091978.3
      Conserved Domains (4) summary
      cd11985
      Location:293 → 345
      SH3_Stac2_C; C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 2 (Stac2)
      pfam16664
      Location:167 → 292
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
      cd20881
      Location:106 → 164
      C1_Stac2; protein kinase C conserved region 1 (C1 domain) found in SH3 and cysteine-rich domain-containing protein 2 (Stac2) and similar proteins
      cl17036
      Location:352 → 403
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83528741..83544583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269538.1 → XP_063125608.1  SH3 and cysteine-rich domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU98
      Related
      ENSRNOP00000108852.1, ENSRNOT00000136635.1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108834.1: Suppressed sequence

      Description
      NM_001108834.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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