U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pid1 phosphotyrosine interaction domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501174, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pid1provided by RGD
    Official Full Name
    phosphotyrosine interaction domain containing 1provided by RGD
    Primary source
    RGD:1560766
    See related
    AllianceGenome:RGD:1560766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab1-119; RGD1560766
    Summary
    Predicted to be involved in several processes, including cellular response to cytokine stimulus; positive regulation of macromolecule biosynthetic process; and regulation of phosphate metabolic process. Predicted to be active in cytoplasm. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 223.7), Lung (RPKM 74.4) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pid1 in Genome Data Viewer
    Location:
    9q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (92732471..92951168, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85284335..85503035, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (91667748..91683468, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AK member 27, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480402 Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC120094725

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effects of NYGGF4 knockdown on insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes. Zhang CM, et al. J Bioenerg Biomembr, 2010 Oct. PMID 21080215
    2. Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes. Zhao Y, et al. Mol Cell Biochem, 2010 Jul. PMID 20165904
    3. NYGGF4 homologous gene expression in 3T3-L1 adipocytes: regulation by FFA and adipokines. Zhao YP, et al. Mol Biol Rep, 2010 Oct. PMID 19894142
    4. Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation. Wang B, et al. Gene, 2006 Sep 1. PMID 16815647
    5. Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt. Zhang CM, et al. Acta Pharmacol Sin, 2009 Jan. PMID 19079291, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leptin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of D-glucose import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    PTB-containing, cubilin and LRP1-interacting protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379478.1 → NP_001366407.1  PTB-containing, cubilin and LRP1-interacting protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K8X3
      Conserved Domains (1) summary
      cd13167
      Location:56 → 194
      PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      92732471..92951168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084113.2 → XP_038940041.1  PTB-containing, cubilin and LRP1-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A692
      Conserved Domains (1) summary
      cd13167
      Location:104 → 242
      PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110493.2: Suppressed sequence

      Description
      NM_001110493.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools