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    PGR7 proton gradient regulation 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821673, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PGR7
    Official Full Name
    proton gradient regulation 7
    Primary source
    TAIR:AT3G21200
    Locus tag
    AT3G21200
    See related
    Araport:AT3G21200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GluTR binding protein; GluTRBP; proton gradient regulation 7
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    Genomic context

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    See PGR7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (7436026..7438011)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ZIM-like 1 Neighboring gene autoinhibited Ca(2+)-ATPase 9 Neighboring gene O-fucosyltransferase family protein Neighboring gene ncRNA Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene MAP kinase kinase 5 Neighboring gene 4-coumarate:CoA ligase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of 5-aminolevulinic acid from glutamate by overexpressing HemA1 and pgr7 from Arabidopsis thaliana in Escherichia coli. Aiguo Z, et al. World J Microbiol Biotechnol, 2019 Oct 31. PMID 31673852
    2. The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase. Richter AS, et al. Elife, 2019 Jun 13. PMID 31194674, Free PMC Article
    3. Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein. Apitz J, et al. Plant Physiol, 2016 Apr. PMID 26884485, Free PMC Article
    4. The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein. Fang Y, et al. Sci Rep, 2016 Jan 22. PMID 26794057, Free PMC Article
    5. Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport. Jung HS, et al. PLoS One, 2010 Jul 21. PMID 20657737, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. binding of heme to the GluTR-binding protein (GBP) inhibits interaction of GBP with the N-terminal regulatory domain of GluTR1, thus making it accessible to the Clp protease.
      Title: The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase.
    2. HemA1 and pgr7 genes from the higher plant Arabidopsis thaliana into recombinant Escherichia coli to overproduce extracellular 5-aminolevulinic acid via the C5 pathway.
      Title: Production of 5-aminolevulinic acid from glutamate by overexpressing HemA1 and pgr7 from Arabidopsis thaliana in Escherichia coli.
    3. ClpS1 and the ClpC1 chaperone as well as the GluTR-binding protein (GBP) interact with the N terminus of GluTR Loss-of function mutants of ClpR2 and ClpC1 proteins show increased GluTR stability, whereas absence of GBP results in decreased GluTR stability. Thus, the Clp protease system and GBP contribute to GluTR accumulation levels, and thereby the rate-limiting ALA synthesis.[GBP]
      Title: Posttranslational Control of ALA Synthesis Includes GluTR Degradation by Clp Protease and Stabilization by GluTR-Binding Protein.
    4. A ternary complex composed of the C-terminal tetratricopepetide-repeat domain of FLU, GBP, and GluTR and a biological role of the ternary complex for the regulation of plant GluTR is reported. [GBP]
      Title: The Arabidopsis glutamyl-tRNA reductase (GluTR) forms a ternary complex with FLU and GluTR-binding protein.
    5. GluTRBP is bound to the thylakoid membrane. Reduction of GluTRBP contents causes heme deficiency.
      Title: An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.
    6. Study identified PGR7 as a novel, conserved nuclear gene that is necessary for efficient photosynthetic electron transport in chloroplasts of Arabidopsis.
      Title: Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_113015.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photosynthetic electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tetrapyrrole biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proton gradient regulation 7
    NP_566678.1
    • proton gradient regulation 7 (PGR7); Has 162 Blast hits to 162 proteins in 45 species: Archae - 0; Bacteria - 40; Metazoa - 0; Fungi - 0; Plants - 91; Viruses - 0; Other Eukaryotes - 31 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7436026..7438011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113015.3 → NP_566678.1  proton gradient regulation 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAE4, Q9LU39
      UniProtKB/TrEMBL
      A0A178VAT7
      Conserved Domains (1) summary
      pfam10615
      Location:204 → 275
      DUF2470; Protein of unknown function (DUF2470)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LU39.1

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