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    EIF4G eukaryotic translation initiation factor 4G [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825194, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EIF4G
    Official Full Name
    eukaryotic translation initiation factor 4G
    Primary source
    TAIR:AT3G60240
    Locus tag
    AT3G60240
    See related
    Araport:AT3G60240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CUCUMOVIRUS MULTIPLICATION 2; CUM2; eukaryotic translation initiation factor 4G; EUKARYOTIC TRANSLATION INITIATION FACTOR 4G
    Summary
    protein synthesis initiation factor 4G (EIF4G). A mutation in this gene (cum2-1) results in decreased accumulation of CMV coat protein in upper, uninoculated leaves. Likely affects cell-to-cell movement of the virus, also affects TCV multiplication.
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    Genomic context

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    See EIF4G in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (22261648..22268496)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene TOXICOS EN LEVADURA 4 Neighboring gene ncRNA Neighboring gene Zinc-binding ribosomal protein family protein Neighboring gene casein kinase II beta chain 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of an Arabidopsis thaliana mutant in which the multiplication of both cucumber mosaic virus and turnip crinkle virus is affected. Yoshii M, et al. J Virol, 1998 Nov. PMID 9765416, Free PMC Article
    2. Eukaryotic translation initiation factor eIFiso4G is required to regulate violaxanthin De-epoxidase expression in Arabidopsis. Chen Z, et al. J Biol Chem, 2014 May 16. PMID 24706761, Free PMC Article
    3. Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana. Nicaise V, et al. FEBS Lett, 2007 Mar 6. PMID 17316629
    4. Substrates related to chromatin and to RNA-dependent processes are modified by Arabidopsis SUMO isoforms that differ in a conserved residue with influence on desumoylation. Budhiraja R, et al. Plant Physiol, 2009 Mar. PMID 19151129, Free PMC Article
    5. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. eIFiso4G expression is required to regulate violaxanthin de-epoxidase expression and to support photosynthetic activity.
      Title: Eukaryotic translation initiation factor eIFiso4G is required to regulate violaxanthin De-epoxidase expression in Arabidopsis.
    2. coordinated and selective recruitment of eIF4E and eIF4G factors at a very early step in potyvirus infection
      Title: Coordinated and selective recruitment of eIF4E and eIF4G factors for potyvirus infection in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084848.1
    NM_001084849.2
    NM_001084850.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4G
    NP_001078317.1
    • eukaryotic translation initiation factor 4G (EIF4G); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: response to virus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT2G24050.1); Has 9534 Blast hits to 6973 proteins in 578 species: Archae - 16; Bacteria - 1115; Metazoa - 4280; Fungi - 1919; Plants - 715; Viruses - 78; Other Eukaryotes - 1411 (source: NCBI BLink).
    NP_001078318.1
    • eukaryotic translation initiation factor 4G (EIF4G); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: response to virus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT2G24050.1); Has 9326 Blast hits to 6766 proteins in 561 species: Archae - 16; Bacteria - 1112; Metazoa - 4125; Fungi - 1859; Plants - 706; Viruses - 74; Other Eukaryotes - 1434 (source: NCBI BLink).
    NP_001078319.1
    • eukaryotic translation initiation factor 4G (EIF4G); FUNCTIONS IN: translation initiation factor activity; INVOLVED IN: response to virus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Initiation factor eIF-4 gamma, MA3 (InterPro:IPR003891), Armadillo-type fold (InterPro:IPR016024), MIF4G-like, type 3 (InterPro:IPR003890), MIF4-like, type 1/2/3 (InterPro:IPR016021); BEST Arabidopsis thaliana protein match is: MIF4G domain-containing protein / MA3 domain-containing protein (TAIR:AT5G57870.1); Has 9538 Blast hits to 7052 proteins in 555 species: Archae - 16; Bacteria - 1070; Metazoa - 4140; Fungi - 1856; Plants - 683; Viruses - 80; Other Eukaryotes - 1693 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22261648..22268496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084849.2 → NP_001078318.1  eukaryotic translation initiation factor 4G [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VEU8
      Conserved Domains (2) summary
      pfam02854
      Location:1094 → 1317
      MIF4G; MIF4G domain
      cl02653
      Location:1544 → 1652
      MA3; MA3 domain

    2. NM_001084850.1 → NP_001078319.1  eukaryotic translation initiation factor 4G [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WVG9, Q76E23, Q9LKQ7, Q9LY39, Q9M4Q5
      UniProtKB/TrEMBL
      A0A7G2ESQ3
      Conserved Domains (2) summary
      pfam02854
      Location:1096 → 1319
      MIF4G; MIF4G domain
      cl02653
      Location:1546 → 1654
      MA3; MA3 domain

    3. NM_001084848.1 → NP_001078317.1  eukaryotic translation initiation factor 4G [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VEU8, A8MR97
      Conserved Domains (2) summary
      pfam02854
      Location:1092 → 1315
      MIF4G; MIF4G domain
      cl02653
      Location:1542 → 1650
      MA3; MA3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76E23.2

    Gene LinkOut

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