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    CPL5 RNA polymerase II carboxy-terminal domain phosphatase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821497, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CPL5
    Official Full Name
    RNA polymerase II carboxy-terminal domain phosphatase-like protein
    Primary source
    TAIR:AT3G19600
    Locus tag
    AT3G19600
    See related
    Araport:AT3G19600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCPL5; C-terminal domain phosphatase-like 5
    Summary
    Encodes a Ser-2-specific RNAPII CTD phosphatase with two tandem-repeated CTD phosphatase domains that belongs to the group III CTD phosphatase-like (CPL) family. It positively regulates ABA and drought responses.
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    Genomic context

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    See CPL5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (6808585..6811808, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene zinc-finger protein 2 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene hypothetical protein (DUF936) Neighboring gene uncharacterized protein Neighboring gene beta-1,4-xylosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtCPL5, a novel Ser-2-specific RNA polymerase II C-terminal domain phosphatase, positively regulates ABA and drought responses in Arabidopsis. Jin YM, et al. New Phytol, 2011 Apr. PMID 21231936
    2. CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II. Hajheidari M, et al. Plant Cell, 2012 Apr. PMID 22547781, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtCPL5 is a unique CTD phosphatase-like 1 family protein that positively regulates abscissic acid-mediated development and drought responses in Arabidopsis.[AtCPL5]
      Title: AtCPL5, a novel Ser-2-specific RNA polymerase II C-terminal domain phosphatase, positively regulates ABA and drought responses in Arabidopsis.
    2. Ser phosphorylation of Arabidopsis thaliana RNAPII CTD is governed by CYCLIN-DEPENDENT KINASE F;1.[RNAPII CTD]
      Title: CDKF;1 and CDKD protein kinases regulate phosphorylation of serine residues in the C-terminal domain of Arabidopsis RNA polymerase II.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase II carboxy-terminal domain phosphatase-like protein
    NP_001319592.1
    • Haloacid dehalogenase-like hydrolase (HAD) superfamily protein; FUNCTIONS IN: phosphoprotein phosphatase activity; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: FCP1-like phosphatase, phosphatase domain (InterPro:IPR011947), NLI interacting factor (InterPro:IPR004274); BEST Arabidopsis thaliana protein match is: Haloacid dehalogenase-like hydrolase (HAD) superfamily protein (TAIR:AT3G19595.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6808585..6811808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338410.1 → NP_001319592.1  RNA polymerase II carboxy-terminal domain phosphatase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LW35, F4JCB2, Q9LJN6, Q9LJN7
      Conserved Domains (1) summary
      TIGR02250
      Location:83 → 241
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JCB2.2

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