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    EYA eyes absent-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818099, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EYA
    Official Full Name
    eyes absent-like protein
    Primary source
    TAIR:AT2G35320
    Locus tag
    AT2G35320
    See related
    Araport:AT2G35320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEYA; EYES ABSENT homolog; T4C15.1; T4C15_1
    Summary
    homologue of the animal Eyes Absent genes. encodes a tyrosine-specific phosphatase. the protein sequence lacks the cys-containing signature of the classical tyrosine phosphatases. belongs to the aspartate-based phosphatases. The enzyme activity is strictly metal-dependent.
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    Genomic context

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    See EYA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (14866832..14868881, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant protein, group 1 protein Neighboring gene Transcriptional factor B3 family protein Neighboring gene RING/U-box superfamily protein Neighboring gene helicase domain-containing protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class. Rayapureddi JP, et al. Biochemistry, 2005 Jan 18. PMID 15641802
    2. Eyes absent proteins: characterization of substrate specificity and phosphatase activity of mutants associated with branchial, otic and renal anomalies. Musharraf A, et al. Chembiochem, 2008 Sep 22. PMID 18759246
    3. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. substrate specificity of the Arabidopsis thaliana homologue (AtEya)
      Title: Eyes absent proteins: characterization of substrate specificity and phosphatase activity of mutants associated with branchial, otic and renal anomalies.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129084.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    eyes absent-like protein
    NP_565803.1
    • EYES ABSENT homolog (EYA); CONTAINS InterPro DOMAIN/s: EYA (InterPro:IPR006545); Has 432 Blast hits to 431 proteins in 74 species: Archae - 0; Bacteria - 0; Metazoa - 379; Fungi - 0; Plants - 40; Viruses - 0; Other Eukaryotes - 13 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14866832..14868881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129084.3 → NP_565803.1  eyes absent-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82162, Q8LAU3, Q93W85
      UniProtKB/TrEMBL
      A0A178VRF2, A0A5S9X444, A0A7G2EBF8
      Conserved Domains (1) summary
      TIGR01658
      Location:18 → 289
      EYA-cons_domain; eyes absent protein conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82162.2

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