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    CAND1 cullin-associated and neddylation dissociated [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814786, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAND1
    Official Full Name
    cullin-associated and neddylation dissociated
    Primary source
    TAIR:AT2G02560
    Locus tag
    AT2G02560
    See related
    Araport:AT2G02560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCAND1; cullin-associated and neddylation dissociated; CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1; ETA2; HEMIVENATA; HVE; T8K22.14; T8K22_14; TIP120
    Summary
    Arabidopsis thaliana homolog of human CAND1 (cullin-associated and neddylation-dissociated). Putative similarity to TBP-interacting protein TIP120. Ubiquitously expressed in plant tissues throughout development. T-DNA insertion mutant plants were completely sterile and resistant to sirtinol and auxin, but not to gibberellins or brassinolide. Displayed developmental phenotypes similar to those of axr1, namely, short petioles, downwardly curling leaves, shorter inflorescence. Required for SCF function and appears to modulate SCF complex cycling. Physically interacts with CUL1.
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    Genomic context

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    See CAND1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    28
    Sequence:
    Chromosome: 2; NC_003071.7 (689784..697707)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene homeobox protein 21 Neighboring gene PIN domain-like family protein Neighboring gene nucleic acid binding/RNA binding protein Neighboring gene cytochrome P450, family 71, subfamily B, polypeptide 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis. Cheng Y, et al. Plant Physiol, 2004 Jun. PMID 15181201, Free PMC Article
    2. The HVE/CAND1 gene is required for the early patterning of leaf venation in Arabidopsis. Alonso-Peral MM, et al. Development, 2006 Oct. PMID 16943276
    3. Molecular variation in a functionally divergent homolog of FCA regulates flowering time in Arabidopsis thaliana. Wang Y, et al. Nat Commun, 2020 Nov 17. PMID 33203912, Free PMC Article
    4. Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase. Chuang HW, et al. Plant Cell, 2004 Jul. PMID 15208392, Free PMC Article
    5. Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases. Quint M, et al. Plant J, 2005 Aug. PMID 16045473, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035877.2
    NM_126312.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    cullin-associated and neddylation dissociated
    NP_001030954.1
    • cullin-associated and neddylation dissociated (CAND1); FUNCTIONS IN: binding; INVOLVED IN: xylem and phloem pattern formation, response to auxin stimulus, vegetative to reproductive phase transition of meristem; LOCATED IN: cell wall, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), TATA-binding protein interacting (TIP20) (InterPro:IPR013932); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_178360.2
    • cullin-associated and neddylation dissociated (CAND1); FUNCTIONS IN: binding; INVOLVED IN: xylem and phloem pattern formation, response to auxin stimulus, vegetative to reproductive phase transition of meristem; LOCATED IN: cell wall, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), TATA-binding protein interacting (TIP20) (InterPro:IPR013932); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      689784..697707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035877.2 → NP_001030954.1  cullin-associated and neddylation dissociated [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWU3
      Conserved Domains (3) summary
      pfam08623
      Location:1051 → 1201
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13646
      Location:927 → 1029
      HEAT_2; HEAT repeats
      sd00044
      Location:887 → 910
      HEAT; HEAT repeat [structural motif]

    2. NM_126312.3 → NP_178360.2  cullin-associated and neddylation dissociated [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64720, Q8L5Y6
      UniProtKB/TrEMBL
      A0A178VV83
      Conserved Domains (3) summary
      pfam08623
      Location:1053 → 1203
      TIP120; TATA-binding protein interacting (TIP20)
      pfam13646
      Location:929 → 1031
      HEAT_2; HEAT repeats
      sd00044
      Location:889 → 912
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L5Y6.1

    Gene LinkOut

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