AGO7 Argonaute family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AGO7
Official Full Name: Argonaute family protein
Primary source: TAIR:AT1G69440
Locus tag: AT1G69440
See related: Araport:AT1G69440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARGONAUTE7; F10D13.11; F10D13_11; ZIP; ZIPPY
Summary: Encodes ARGONAUTE7, a member of the ARGONAUTE family, characterised by the presence of PAZ and PIWI domains. Involved in the regulation of developmental timing. Required for the accumulation of TAS3 ta-siRNAs but not for accumulation of miR171, miR173, miR390 or mi391. Localized in mature rosette leaves and floral buds.
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Genomic context

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See AGO7 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (26101407..26105328, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of Female Germline Specification via Small RNA Mobility in Arabidopsis.
Title: Regulation of Female Germline Specification via Small RNA Mobility in Arabidopsis.
Antiviral ARGONAUTEs Against Turnip Crinkle Virus Revealed by Image-Based Trait Analysis.
Title: Antiviral ARGONAUTEs Against Turnip Crinkle Virus Revealed by Image-Based Trait Analysis.
Arabidopsis ARGONAUTE7 selects microRNA390 through multiple checkpoints during RISC assembly.
Title: Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly.
Complementation analyses in ago mutant plants revealed that the catalytic residues of AGO1, AGO2, and AGO7 are required to restore the defects of Arabidopsis ago1-25, ago2-1, and zip-1 (AGO7-defective) mutants, respectively.
Title: Functional analysis of three Arabidopsis ARGONAUTES using slicer-defective mutants.
It was shown that AGO7 is needed in the cytoplasm and membranous siRNA bodies for the processing of the TAS3 precursor, showing a hitherto unknown role for membrane-associated ribonucleoparticles in trans-acting-siRNA biogenesis and AGO action in plants.
Title: Cytoplasmic Arabidopsis AGO7 accumulates in membrane-associated siRNA bodies and is required for ta-siRNA biogenesis.
AGO1 and AGO7 function to ensure efficient clearance of viral RNAs and establish that AGO1 is capable of targeting viral RNAs with more compact structures, whereas AGO7 and RDR6 favor less structured RNA targets
Title: Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.
Study shows that miR390-ARGONAUTE7 complexes function in distinct cleavage or noncleavage modes at two target sites in TAS3a transcripts.
Title: Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation.
RDR6, SGS3 and AGO7 act in the same pathway, which genetically interacts with the AS1-AS2 pathway for leaf development.
Title: Genetic interaction between the AS1-AS2 and RDR6-SGS3-AGO7 pathways for leaf morphogenesis.

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General gene information

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Homology

Orthologs from OrthoDB

NM_105611.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNAi-mediated antiviral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lsiRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ta-siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vegetative phase change	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Argonaute family protein

NP_177103.1

ARGONAUTE7 (AGO7); FUNCTIONS IN: nucleic acid binding; INVOLVED IN: production of ta-siRNAs involved in RNA interference, vegetative phase change, production of lsiRNA involved in RNA interference, regulation of development, heterochronic, gene silencing by miRNA; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Argonaute/Dicer protein, PAZ (InterPro:IPR003100), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis thaliana protein match is: Stabilizer of iron transporter SufD / Polynucleotidyl transferase (TAIR:AT1G48410.1); Has 2067 Blast hits to 2008 proteins in 214 species: Archae - 0; Bacteria - 0; Metazoa - 1082; Fungi - 299; Plants - 502; Viruses - 5; Other Eukaryotes - 179 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

26101407..26105328 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105611.5 → NP_177103.1 Argonaute family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177103.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C793

UniProtKB/TrEMBL

A0A178WCZ9, A0A5S9WQV8, A0A654EMJ2

Conserved Domains (4) summary

cd04657
Location:532 → 949

Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

pfam02170
Location:390 → 495

PAZ; PAZ domain

pfam08699
Location:316 → 366

ArgoL1; Argonaute linker 1 domain

pfam16486
Location:220 → 306

ArgoN; N-terminal domain of argonaute