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    AAE14 acyl-activating enzyme 14 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839932, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAE14
    Official Full Name
    acyl-activating enzyme 14
    Primary source
    TAIR:AT1G30520
    Locus tag
    AT1G30520
    See related
    Araport:AT1G30520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-activating enzyme 14; F26G16.14; F26G16_14
    Summary
    Encodes a chloroplast O-succinylbenzoyl-CoA ligase. Involved in phylloquinone biosynthesis. Knock mutant is seedling lethal.
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    Genomic context

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    See AAE14 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (10810397..10813779)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene root FNR 2 Neighboring gene GATA zinc finger protein Neighboring gene ncRNA Neighboring gene UDP-glucosyl transferase 78D1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AAE14 gene encodes the Arabidopsis o-succinylbenzoyl-CoA ligase that is essential for phylloquinone synthesis and photosystem-I function. Kim HU, et al. Plant J, 2008 Apr. PMID 18208520
    2. The proteome map of spinach leaf peroxisomes indicates partial compartmentalization of phylloquinone (vitamin K1) biosynthesis in plant peroxisomes. Babujee L, et al. J Exp Bot, 2010 Mar. PMID 20150517
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AAE14 was identified as the o-succinylbenzoyl-coenzyme A (OSB-CoA) ligase acting in phylloquinone synthesis.
      Title: The AAE14 gene encodes the Arabidopsis o-succinylbenzoyl-CoA ligase that is essential for phylloquinone synthesis and photosystem-I function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001332904.1
    NM_001332905.1
    NM_102789.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables o-succinylbenzoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables o-succinylbenzoate-CoA ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phylloquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-activating enzyme 14
    NP_174340.2
    • acyl-activating enzyme 14 (AAE14); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G19010.1); Has 73301 Blast hits to 67448 proteins in 3614 species: Archae - 1088; Bacteria - 49563; Metazoa - 3259; Fungi - 3557; Plants - 2200; Viruses - 1; Other Eukaryotes - 13633 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10810397..10813779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332903.1 → NP_001322322.1  acyl-activating enzyme 14 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYJ1, Q9S9P7
      UniProtKB/TrEMBL
      A0A178W8C3
      Conserved Domains (2) summary
      PLN02860
      Location:1 → 560
      PLN02860; o-succinylbenzoate-CoA ligase
      cl17068
      Location:172 → 546
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_102789.5 → NP_174340.2  acyl-activating enzyme 14 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174340.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYJ1, Q9S9P7
      UniProtKB/TrEMBL
      A0A178W8C3
      Conserved Domains (2) summary
      PLN02860
      Location:1 → 560
      PLN02860; o-succinylbenzoate-CoA ligase
      cl17068
      Location:172 → 546
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. NM_001332905.1 → NP_001322321.1  acyl-activating enzyme 14 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W8C3, A0A1P8ATR3

    4. NM_001332904.1 → NP_001322320.1  acyl-activating enzyme 14 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W8C3, A0A1P8ATR3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYJ1.1

    Gene LinkOut

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