STN1 Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: STN1
Official Full Name: Nucleic acid-binding, OB-fold-like protein
Primary source: TAIR:AT1G07130
Locus tag: AT1G07130
See related: Araport:AT1G07130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSTN1; F10K1.17; F10K1_17
Summary: Encodes a protein with similarity to yeast STN1, an OB fold protein involved in protecting yeast telomeres. In Arabidopsis, loss of STN1 function mutations exhibit gross morphological abnormalities and defects in telomere architecture and maintenance. STN1 likely plays a role in telomere end capping.
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Genomic context

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See STN1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (2187776..2188733)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STN1 plays a genome-wide role in DNA replication and telomere stability.
Title: Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.
POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
Title: ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis.
CTC1 participates in telomere maintenance in diverse species and that a CST-like complex is required for telomere integrity in multicellular organisms.
Title: Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.
AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)
Title: STN1 protects chromosome ends in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100586.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Nucleic acid-binding, OB-fold-like protein

NP_563781.1

STN1; FUNCTIONS IN: nucleic acid binding; INVOLVED IN: telomere capping; LOCATED IN: nuclear chromosome, telomeric region; EXPRESSED IN: root, seed; EXPRESSED DURING: E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), Nucleic acid binding, OB-fold, tRNA/helicase-type (InterPro:IPR004365); Has 110 Blast hits to 110 proteins in 42 species: Archae - 0; Bacteria - 0; Metazoa - 57; Fungi - 2; Plants - 47; Viruses - 0; Other Eukaryotes - 4 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

2187776..2188733

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100586.2 → NP_563781.1 Nucleic acid-binding, OB-fold-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563781.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LMK5

UniProtKB/TrEMBL

A0A178W9Z5, A0A5S9T238

Conserved Domains (1) summary

cd04483
Location:42 → 133

hOBFC1_like; A subfamily of OB folds similar to that found in human OB fold containing protein 1 (hOBFC1). Members of this group belong to the Replication protein A subunit 2 (RPA2) family of OB folds. RPA is a nuclear ssDNA binding protein (SSB) which appears to be ...