STK K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: STK
Official Full Name: K-box region and MADS-box transcription factor family protein
Primary source: TAIR:AT4G09960
Locus tag: AT4G09960
See related: Araport:AT4G09960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AGAMOUS-like 11; AGL11; SEEDSTICK; T5L19.90; T5L19_90
Summary: Encodes a MADS box transcription factor expressed in the carpel and ovules. Plays a maternal role in fertilization and seed development.
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Genomic context

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See STK in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (6236375..6241281, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antagonistic MADS-box transcription factors SEEDSTICK and SEPALLATA3 form a transcriptional regulatory network that regulates seed oil accumulation.
Title: Antagonistic MADS-box transcription factors SEEDSTICK and SEPALLATA3 form a transcriptional regulatory network that regulates seed oil accumulation.
Genetic Interaction of SEEDSTICK, GORDITA and AUXIN RESPONSE FACTOR 2 during Seed Development.
Title: Genetic Interaction of SEEDSTICK, GORDITA and AUXIN RESPONSE FACTOR 2 during Seed Development.
SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
Title: SEEDSTICK Controls Arabidopsis Fruit Size by Regulating Cytokinin Levels and FRUITFULL.
BPC transcription factors and a Polycomb Group protein confine the expression of the ovule identity gene SEEDSTICK in Arabidopsis.
Title: BPC transcription factors and a Polycomb Group protein confine the expression of the ovule identity gene SEEDSTICK in Arabidopsis.
The RNA-dependent DNA methylation pathway is required to restrict SPOROCYTELESS/NOZZLE expression to specify a single female germ cell precursor in Arabidopsis.
Title: The RNA-dependent DNA methylation pathway is required to restrict SPOROCYTELESS/NOZZLE expression to specify a single female germ cell precursor in Arabidopsis.
the simultaneous loss of NTT and STK activity affects polysaccharide and lipid deposition and septum fusion, and delays entry of septum cells to their normal degradation program.
Title: New roles of NO TRANSMITTING TRACT and SEEDSTICK during medial domain development in Arabidopsis fruits.
studies reveal a molecular network controlled by STK that regulates cell wall properties of the seed coat, demonstrating that developmental regulators controlling organ identity also coordinate specific aspects of cell wall characteristics.
Title: The Developmental Regulator SEEDSTICK Controls Structural and Mechanical Properties of the Arabidopsis Seed Coat.
STK might recruit or regulate histone modifying factors to control their activity in Arabidopsis.
Title: SEEDSTICK is a master regulator of development and metabolism in the Arabidopsis seed coat.
Data indicate that SEEDSTICK (STK) and SEPALLATA3 (SEP3) dimers can induce loop formation in the VERDANDI (VDD) promoter by binding to two nearby CC(A/T)6GG (CArG) boxes essential for promoter activity.
Title: MADS domain transcription factors mediate short-range DNA looping that is essential for target gene expression in Arabidopsis.
STK and ABS played a role in the maternal control of endothelium formation, as the abs stk double mutant completely lacks endothelium.
Title: The MADS box genes SEEDSTICK and ARABIDOPSIS Bsister play a maternal role in fertilization and seed development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001084895.1

Supported by ESTs:

NM_001340645.1

Supported by ESTs:

NM_001340646.1

Supported by ESTs:

NM_001340647.1

Supported by ESTs:

NM_117064.7

Supported by ESTs:

NM_179020.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carpel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within integument development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within mucilage metabolic process involved in seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant ovule development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plant ovule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of cell division	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of double fertilization forming a zygote and endosperm	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed coat development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in stigma papilla	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: K-box region and MADS-box transcription factor family protein

NP_001078364.1

SEEDSTICK (STK); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT2G42830.1); Has 7126 Blast hits to 7125 proteins in 906 species: Archae - 0; Bacteria - 9; Metazoa - 642; Fungi - 296; Plants - 6075; Viruses - 0; Other Eukaryotes - 104 (source: NCBI BLink).

NP_001319889.1

SEEDSTICK (STK); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT2G42830.2).

NP_192734.1

SEEDSTICK (STK); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT2G42830.1); Has 7129 Blast hits to 7128 proteins in 907 species: Archae - 0; Bacteria - 6; Metazoa - 637; Fungi - 309; Plants - 6073; Viruses - 0; Other Eukaryotes - 104 (source: NCBI BLink).

NP_849351.1

SEEDSTICK (STK); FUNCTIONS IN: protein binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, ovule development, carpel development; LOCATED IN: nucleus; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 4 anthesis, C globular stage, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT4G18960.1); Has 6909 Blast hits to 6907 proteins in 896 species: Archae - 0; Bacteria - 5; Metazoa - 630; Fungi - 312; Plants - 5881; Viruses - 0; Other Eukaryotes - 81 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

6236375..6241281 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001340645.1 → NP_001319889.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XR61, A0A654FMU7, F4JKV2
NM_117064.7 → NP_192734.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38836, Q8VZ36

UniProtKB/TrEMBL

A0A178UX25

Conserved Domains (2) summary

cd00265
Location:2 → 76

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:89 → 172

K-box; K-box region
NM_001340646.1 → NP_001329611.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B889, A0A5S9XR61, A0A654FMU7

Conserved Domains (2) summary

cd00265
Location:12 → 86

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:99 → 182

K-box; K-box region
NM_001084895.1 → NP_001078364.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078364.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XR61, A0A654FMU7, A8MQL9

Conserved Domains (2) summary

cd00265
Location:28 → 102

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:115 → 196

K-box; K-box region
NM_001340647.1 → NP_001329612.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B895
NM_179020.5 → NP_849351.1 K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849351.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38836

Conserved Domains (2) summary

cd00265
Location:2 → 76

MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...

pfam01486
Location:89 → 156

K-box; K-box region