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    GOX3 Aldolase-type TIM barrel family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827563, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GOX3
    Official Full Name
    Aldolase-type TIM barrel family protein
    Primary source
    TAIR:AT4G18360
    Locus tag
    AT4G18360
    See related
    Araport:AT4G18360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28J12.20; F28J12_20; glycolate oxidase 3
    Summary
    Encodes a glycolate oxidase that modulates reactive oxygen species-mediated signal transduction during nonhost resistance.
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    Genomic context

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    See GOX3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (10145895..10148764, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene nine-cis-epoxycarotenoid dioxygenase 2 Neighboring gene ncRNA Neighboring gene DEGP protease 5 Neighboring gene Small nuclear ribonucleoprotein family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis. Engqvist MK, et al. Plant Physiol, 2015 Oct. PMID 26246447, Free PMC Article
    2. Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis. Rojas CM, et al. Plant Cell, 2012 Jan. PMID 22286136, Free PMC Article
    3. Proteome analysis of peroxisomes from etiolated Arabidopsis seedlings identifies a peroxisomal protease involved in β-oxidation and development. Quan S, et al. Plant Physiol, 2013 Dec. PMID 24130194, Free PMC Article
    4. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GOX3(At4g18360) is the enzyme that metabolizes l-lactate to pyruvate.GOX3 is predominantly present in roots and mature to aging leaves but is largely absent from young photosynthetic leaves.[
      Title: GLYCOLATE OXIDASE3, a Glycolate Oxidase Homolog of Yeast l-Lactate Cytochrome c Oxidoreductase, Supports l-Lactate Oxidation in Roots of Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001084937.1
    NM_001341276.1
    NM_001341277.1
    NM_117946.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aldolase-type TIM barrel family protein
    NP_001078406.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2); Has 9948 Blast hits to 9918 proteins in 1541 species: Archae - 28; Bacteria - 4496; Metazoa - 367; Fungi - 686; Plants - 255; Viruses - 0; Other Eukaryotes - 4116 (source: NCBI BLink).
    NP_193570.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity, oxidoreductase activity, FMN binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14420.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10145895..10148764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117946.3 → NP_193570.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRC3, O49506
      UniProtKB/TrEMBL
      A0A654FQJ9
      Conserved Domains (2) summary
      PLN02493
      Location:1 → 364
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
      cd02809
      Location:8 → 351
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    2. NM_001341276.1 → NP_001329915.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B993

    3. NM_001084937.1 → NP_001078406.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UV33, A0A654FQJ9
      Conserved Domains (1) summary
      cd02809
      Location:8 → 307
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    4. NM_001341277.1 → NP_001329914.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRC3, O49506
      UniProtKB/TrEMBL
      A0A654FQJ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49506.1

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