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    SIX3 SIX homeobox 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 616756, updated on 30-Jan-2025

    Summary

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    Official Symbol
    SIX3provided by VGNC
    Official Full Name
    SIX homeobox 3provided by VGNC
    Primary source
    VGNC:VGNC:34640
    See related
    BGD:BT15895; EnsemblRapid:ENSBTAG00070022926
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SIX3 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (27357851..27399409)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene uncharacterized LOC112448771 Neighboring gene SIX homeobox 2 Neighboring gene transfer RNA cysteine (anticodon GCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeobox protein SIX3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193124.2 → NP_001180053.1  homeobox protein SIX3

      See identical proteins and their annotated locations for NP_001180053.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000011
      UniProtKB/TrEMBL
      A0AAA9TFK6
      Conserved Domains (2) summary
      cd00086
      Location:204 → 252
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:83 → 196
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27357851..27399409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010809999.4 → XP_010808301.2  homeobox protein SIX3 isoform X1

      UniProtKB/TrEMBL
      A0AAA9S3G4
      Conserved Domains (2) summary
      cd00086
      Location:225 → 273
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:104 → 217
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

    2. XM_059891516.1 → XP_059747499.1  homeobox protein SIX3 isoform X2

      UniProtKB/TrEMBL
      A0AAA9TFK6, E1BMT1
      Related
      ENSBTAP00070030986.1, ENSBTAT00070051623.1
    Nucleotide Protein Strain
    Heading Accession and Version

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