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    FURIN furin, paired basic amino acid cleaving enzyme [ Bos taurus (domestic cattle) ]

    Gene ID: 281374, updated on 27-Dec-2024

    Summary

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    Official Symbol
    FURINprovided by VGNC
    Official Full Name
    furin, paired basic amino acid cleaving enzymeprovided by VGNC
    Primary source
    VGNC:VGNC:29146
    See related
    BGD:BT11212; Ensembl:ENSBTAG00000002939
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PACE
    Orthologs
    human mouse all
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    Genomic context

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    See FURIN in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (21780691..21797132, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene FES proto-oncogene, tyrosine kinase Neighboring gene BLM RecQ like helicase Neighboring gene uncharacterized LOC107131599 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene CREB regulated transcription coactivator 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation. Vey M, et al. J Cell Biol, 1994 Dec. PMID 7806563, Free PMC Article
    2. Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors. Maruotti J, et al. Mol Reprod Dev, 2012 Jul. PMID 22573702
    3. Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue. Li Q, et al. J Anim Sci, 2019 Feb 1. PMID 30476104, Free PMC Article
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide hormone processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    furin
    Names
    dibasic-processing enzyme
    furin, membrane associated receptor protein
    paired basic amino acid cleaving enzyme
    paired basic amino acid residue-cleaving enzyme
    trans Golgi network protease furin
    NP_776561.1
    XP_024837364.1
    XP_024837365.1
    XP_024837366.1
    XP_059734924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174136.2 → NP_776561.1  furin precursor

      See identical proteins and their annotated locations for NP_776561.1

      Status: PROVISIONAL

      Source sequence(s)
      X75956
      UniProtKB/Swiss-Prot
      Q28193
      UniProtKB/TrEMBL
      A0A3Q1M727
      Related
      ENSBTAP00000065278.1, ENSBTAT00000072776.1
      Conserved Domains (5) summary
      cd04059
      Location:113 → 402
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638 → 675
      FU; Furin-like repeats
      pfam00082
      Location:144 → 427
      Peptidase_S8; Subtilase family
      pfam01483
      Location:484 → 570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21780691..21797132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878941.1 → XP_059734924.1  furin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M727, B0JYR0

    2. XM_024981598.2 → XP_024837366.1  furin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M727, B0JYR0
      Conserved Domains (4) summary
      cd04059
      Location:113 → 402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638 → 675
      FU; Furin-like repeats
      pfam01483
      Location:484 → 570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    3. XM_024981597.2 → XP_024837365.1  furin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M727, B0JYR0
      Conserved Domains (4) summary
      cd04059
      Location:113 → 402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638 → 675
      FU; Furin-like repeats
      pfam01483
      Location:484 → 570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    4. XM_024981596.2 → XP_024837364.1  furin isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M727, B0JYR0
      Conserved Domains (4) summary
      cd04059
      Location:113 → 402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638 → 675
      FU; Furin-like repeats
      pfam01483
      Location:484 → 570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33 → 107
      S8_pro-domain; Peptidase S8 pro-domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28193.1 GenPept UniProtKB/Swiss-Prot:Q28193

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