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    CYM chymosin [ Bos taurus (domestic cattle) ]

    Gene ID: 529879, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CYMprovided by VGNC
    Official Full Name
    chymosinprovided by VGNC
    Primary source
    VGNC:VGNC:108923
    See related
    BGD:BT11742; Ensembl:ENSBTAG00000010565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CPC; Chy
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    Genomic context

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    See CYM in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (32944105..32954997, complement)

    Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132344988 Neighboring gene potassium voltage-gated channel subfamily A member 10 Neighboring gene prokineticin 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Camel and bovine chymosin: the relationship between their structures and cheese-making properties. Langholm Jensen J, et al. Acta Crystallogr D Biol Crystallogr, 2013 May. PMID 23633601, Free PMC Article
    2. Short communication: Identification and characterization of multiple splicing forms of bovine prochymosin mRNA. Zinovieva N, et al. J Dairy Sci, 2002 Dec. PMID 12512621
    3. Nucleotide sequence of calf prorennin cDNA cloned in Escherichia coli. Nishimori K, et al. J Biochem, 1982 Mar. PMID 6804449
    4. Molecular cloning and nucleotide sequence of cDNA coding for calf preprochymosin. Harris TJ, et al. Nucleic Acids Res, 1982 Apr 10. PMID 6283469, Free PMC Article
    5. Molecular cloning and characterization of double-stranded cDNA coding for bovine chymosin. Moir D, et al. Gene, 1982 Jul-Aug. PMID 6183168

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structure of bovine chymosin shows relationship with cheese making properties
      Title: Camel and bovine chymosin: the relationship between their structures and cheese-making properties.
    2. molecular dynamics simulation of bovine chymosin complexed with the P9-P70 residues of bovine kappa-casein
      Title: Bovine chymosin: a computational study of recognition and binding of bovine kappa-casein.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chymosin
    Names
    preprorennin
    prochymosin
    rennin
    NP_851337.1
    XP_005204185.1
    XP_005204186.1
    XP_005204187.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_180994.2 → NP_851337.1  chymosin preproprotein

      See identical proteins and their annotated locations for NP_851337.1

      Status: PROVISIONAL

      Source sequence(s)
      J00003
      UniProtKB/TrEMBL
      A0A3Q1MMC7
      Related
      ENSBTAP00000013970.3, ENSBTAT00000013970.4
      Conserved Domains (3) summary
      cd05478
      Location:64 → 379
      pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
      pfam00026
      Location:73 → 380
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:19 → 47
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      32944105..32954997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005204130.5 → XP_005204187.1  chymosin isoform X3

      UniProtKB/TrEMBL
      Q8SPG9
      Conserved Domains (3) summary
      pfam00026
      Location:73 → 309
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:19 → 47
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64 → 308
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    2. XM_005204129.5 → XP_005204186.1  chymosin isoform X2

      UniProtKB/TrEMBL
      Q8SPH0
      Conserved Domains (3) summary
      pfam00026
      Location:73 → 342
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:19 → 47
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64 → 341
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    3. XM_005204128.5 → XP_005204185.1  chymosin isoform X1

      UniProtKB/TrEMBL
      Q8SPH1
      Related
      ENSBTAP00000072281.1, ENSBTAT00000068123.2
      Conserved Domains (3) summary
      pfam00026
      Location:73 → 347
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:19 → 47
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64 → 346
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00794.3 GenPept UniProtKB/Swiss-Prot:P00794

    Gene LinkOut

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