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    TKFC triokinase and FMN cyclase [ Bos taurus (domestic cattle) ]

    Gene ID: 512373, updated on 30-Jan-2025

    Summary

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    Official Symbol
    TKFCprovided by VGNC
    Official Full Name
    triokinase and FMN cyclaseprovided by VGNC
    Primary source
    VGNC:VGNC:56287
    See related
    BGD:BT15501; EnsemblRapid:ENSBTAG00070029559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DAK
    Orthologs
    human mouse all
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    Genomic context

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    See TKFC in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 29 NC_037356.1 (39842561..39854638)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene von Willebrand factor C and EGF domains Neighboring gene damage specific DNA binding protein 1 Neighboring gene cytochrome b561 family member A3 Neighboring gene transmembrane protein 138 Neighboring gene transmembrane protein 216 Neighboring gene cleavage and polyadenylation specific factor 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037356.1 Chromosome 29 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
    2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp586B1621

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    triokinase/FMN cyclase
    Names
    bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
    NP_001019695.2
    XP_005226963.1
    XP_005226964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024524.3 → NP_001019695.2  triokinase/FMN cyclase

      See identical proteins and their annotated locations for NP_001019695.2

      Status: PROVISIONAL

      Source sequence(s)
      BC126551
      UniProtKB/Swiss-Prot
      Q58DK4
      UniProtKB/TrEMBL
      A0JN77
      Related
      ENSBTAP00070041045.1, ENSBTAT00070067221.1
      Conserved Domains (1) summary
      cl10557
      Location:4 → 558
      Dak1; Dak1 domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      39842561..39854638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005226907.5 → XP_005226964.1  triokinase/FMN cyclase isoform X2

      UniProtKB/Swiss-Prot
      Q58DK4
      Conserved Domains (1) summary
      cl10557
      Location:1 → 488
      Dak1; Dak1 domain

    2. XM_005226906.5 → XP_005226963.1  triokinase/FMN cyclase isoform X1

      See identical proteins and their annotated locations for XP_005226963.1

      UniProtKB/Swiss-Prot
      Q58DK4
      UniProtKB/TrEMBL
      A0JN77
      Related
      ENSBTAP00070041005.1, ENSBTAT00070067158.1
      Conserved Domains (1) summary
      cl10557
      Location:4 → 558
      Dak1; Dak1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58DK4.1 GenPept UniProtKB/Swiss-Prot:Q58DK4

    Gene LinkOut

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    Research Materials