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    CEACAM1 CEA cell adhesion molecule 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 404118, updated on 27-Dec-2024

    Summary

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    Gene symbol
    CEACAM1
    Gene description
    CEA cell adhesion molecule 1
    See related
    Ensembl:ENSBTAG00000005615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CEACAM8
    Orthologs
    human all
    NEW
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    Genomic context

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    See CEACAM1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (50818011..50837829)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100847120 Neighboring gene uncharacterized LOC132342857 Neighboring gene uncharacterized LOC132342858 Neighboring gene lipase E, hormone sensitive type Neighboring gene cornifelin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution. Kammerer R, et al. Gene, 2004 Sep 15. PMID 15363850
    2. Ceacam1 deletion causes vascular alterations in large vessels. Najjar SM, et al. Am J Physiol Endocrinol Metab, 2013 Aug 15. PMID 23800882, Free PMC Article
    3. CEACAM1: a key regulator of vascular permeability. Nouvion AL, et al. J Cell Sci, 2010 Dec 15. PMID 21081647
    4. Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors. Merkt W, et al. Eur J Immunol, 2015 Jul. PMID 25824372
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data show that human and bovine CEACAM1 can both inhibit NK-cell cytotoxicity although they differ in their intracellular signaling motifs
      Title: Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors.
    2. Data from cultured aortic endothelial cells suggest that CEACAM1 is involved in regulation of vascular endothelial cell reactions to oxidative stress/lipid peroxidation and in regulation of nitric oxide production in large vessels such as aorta.
      Title: Ceacam1 deletion causes vascular alterations in large vessels.
    3. This data represents the first report of a functional link between CEACAM1 and the VEGFR2/Akt/eNOS-mediated vascular permeability pathway.
      Title: CEACAM1: a key regulator of vascular permeability.
    4. CEACAM1 has two alleles and serves as a pathogen receptor in cattle.
      Title: Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC142545

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of immune system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell adhesion molecule CEACAM1
    Names
    CEACAM1b-3L
    CEACAM1b-3Ls
    CEACAM1b-3S
    CEACAM1b-3Ss
    carcinoembryonic antigen related cell adhesion molecule 1
    carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    carcinoembryonic antigen-related cell adhesion molecule 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205788.1 → NP_991357.1  cell adhesion molecule CEACAM1 precursor

      See identical proteins and their annotated locations for NP_991357.1

      Status: PROVISIONAL

      Source sequence(s)
      AY345127
      UniProtKB/TrEMBL
      Q6VAN7, Q6VAN8
      Related
      ENSBTAP00000009007.6, ENSBTAT00000009007.7
      Conserved Domains (3) summary
      cd05774
      Location:36 → 137
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:242 → 323
      IG_like; Immunoglobulin like
      cl11960
      Location:143 → 231
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50818011..50837829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977969.2 → XP_024833737.1  cell adhesion molecule CEACAM1 isoform X1

      UniProtKB/TrEMBL
      Q6VAN7
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:146 → 234
      Ig; Immunoglobulin domain

    2. XM_059876523.1 → XP_059732506.1  cell adhesion molecule CEACAM1 isoform X2

      UniProtKB/TrEMBL
      Q6VAN6
      Related
      ENSBTAP00000073656.2, ENSBTAT00000069303.2

    3. XM_059876525.1 → XP_059732508.1  cell adhesion molecule CEACAM1 isoform X3

      UniProtKB/TrEMBL
      E1BMI5, Q6VAN5

    4. XM_059876522.1 → XP_059732505.1  cell adhesion molecule CEACAM1 isoform X2

      UniProtKB/TrEMBL
      Q6VAN6
      Related
      ENSBTAP00000065766.2, ENSBTAT00000071386.2

    5. XM_059876524.1 → XP_059732507.1  cell adhesion molecule CEACAM1 isoform X3

      UniProtKB/TrEMBL
      E1BMI5, Q6VAN5
      Related
      ENSBTAP00000007371.6, ENSBTAT00000007371.6

    RNA

    1. XR_003030151.2 RNA Sequence

    2. XR_003030153.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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