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    BIO1 adenosylmethionine-8-amino-7-oxononanoate transaminase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835863, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIO1
    Official Full Name
    adenosylmethionine-8-amino-7-oxononanoate transaminase
    Primary source
    TAIR:AT5G57590
    Locus tag
    AT5G57590
    See related
    Araport:AT5G57590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    biotin auxotroph 1; MUA2.17; MUA2_17
    Summary
    Encodes a bifunctional enzyme with both dethiobiotin synthetase and diaminopelargonic acid aminotransferase activities that is involved in biotin synthesis.
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    Genomic context

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    See BIO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (23318399..23322770, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene GCK domain-containing protein Neighboring gene Calmodulin-binding protein Neighboring gene kinase superfamily with octicosapeptide/Phox/Bem1p domain-containing protein Neighboring gene myb domain protein 36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis. Cobessi D, et al. Plant Cell, 2012 Apr. PMID 22547782, Free PMC Article
    2. A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Muralla R, et al. Plant Physiol, 2008 Jan. PMID 17993549, Free PMC Article
    3. The role of biotin in regulating 3-methylcrotonyl-coenzyme a carboxylase expression in Arabidopsis. Che P, et al. Plant Physiol, 2003 Mar. PMID 12644697, Free PMC Article
    4. Complementation of an Arabidopsis thaliana biotin auxotroph with an Escherichia coli biotin biosynthetic gene. Patton DA, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676868
    5. SUCROSE TRANSPORTER 5 supplies Arabidopsis embryos with biotin and affects triacylglycerol accumulation. Pommerrenig B, et al. Plant J, 2013 Feb. PMID 23031218, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The BIO3-BIO1 fusion protein is the sole protein form produced by the BIO3-BIO1 locus in Arabidopsis.[BIO3-BIO1]
      Title: Biochemical and structural characterization of the Arabidopsis bifunctional enzyme dethiobiotin synthetase-diaminopelargonic acid aminotransferase: evidence for substrate channeling in biotin synthesis.
    2. The characterization of dethiobiotin synthetase (BIO3) in relationship to BIO1, the second enzyme in the biotin synthesis pathway, is reported.
      Title: A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_125140.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosylmethionine-8-amino-7-oxononanoate transaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables dethiobiotin synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within biotin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within biotin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosylmethionine-8-amino-7-oxononanoate transaminase
    NP_200567.2
    • biotin auxotroph 1 (BIO1); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase class-III (InterPro:IPR005814), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: HOPW1-1-interacting 1 (TAIR:AT1G80600.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23318399..23322770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125140.4 → NP_200567.2  adenosylmethionine-8-amino-7-oxononanoate transaminase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200567.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B0F481, B0F482, Q681L5, Q6NQL9, Q9FKL4, Q9FKL5
      UniProtKB/TrEMBL
      A0A178UCN9, A0A5S9YF53, A0A654GBZ1
      Conserved Domains (1) summary
      PLN02974
      Location:22 → 828
      PLN02974; adenosylmethionine-8-amino-7-oxononanoate transaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0F481.1

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