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    SDG25 SET domain protein 25 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834246, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SDG25
    Official Full Name
    SET domain protein 25
    Primary source
    TAIR:AT5G42400
    Locus tag
    AT5G42400
    See related
    Araport:AT5G42400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS TRITHORAX-RELATED7; ATXR7; MDH9.9; MDH9_9; SET domain protein 25
    Summary
    Encodes ATXR7 (ARABIDOPSIS TRITHORAX-RELATED7), required for histone H3-K4 methylation and for transcriptional activation of Flowering Locus C.
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    Genomic context

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    See SDG25 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    19
    Sequence:
    Chromosome: 5; NC_003076.8 (16953515..16961245, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene calmodulin like 37 Neighboring gene Insulinase (Peptidase family M16) family protein Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene Nucleotide-sugar transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global Regulation of Plant Immunity by Histone Lysine Methyl Transferases. Lee S, et al. Plant Cell, 2016 Jul. PMID 27354553, Free PMC Article
    2. SET DOMAIN GROUP25 encodes a histone methyltransferase and is involved in FLOWERING LOCUS C activation and repression of flowering. Berr A, et al. Plant Physiol, 2009 Nov. PMID 19726574, Free PMC Article
    3. ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C. Tamada Y, et al. Plant Cell, 2009 Oct. PMID 19855050, Free PMC Article
    4. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Xia S, et al. Plant Physiol, 2013 Jul. PMID 23690534, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SDG8 and SDG25 contribute to plant immunity directly through HLM or indirectly through H2Bubn and by regulating expression of plant immunity genes, accumulation of lipids, biosynthesis of carotenoids, and maintenance of cuticle integrity.
      Title: Global Regulation of Plant Immunity by Histone Lysine Methyl Transferases.
    2. ATXR7 is required for the regulation of SNC1 and RPP4 expression, suggesting that MOS9 functions together with ATXR7 to regulate the expression of NB-LRR-encoding Resistance genes. [ATXR7]
      Title: Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation.
    3. H3K4 methylases, atxr7, appear to be required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
      Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
    4. Expression of FLC is down-regulated in the sdg25-1 histone methyltransferase mutant, and H3K36 dimethylation is slightly down-regulated at some regions of FLC.
      Title: SET DOMAIN GROUP25 encodes a histone methyltransferase and is involved in FLOWERING LOCUS C activation and repression of flowering.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344444.1
    NM_001344449.1
    NM_001344450.1
    NM_001344451.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SET domain protein 25
    NP_001318731.1
    • SET domain protein 25 (SDG25); CONTAINS InterPro DOMAIN/s: SET domain (InterPro:IPR001214), GYF (InterPro:IPR003169); BEST Arabidopsis thaliana protein match is: homologue of trithorax (TAIR:AT2G31650.1); Has 5838 Blast hits to 5683 proteins in 501 species: Archae - 3; Bacteria - 461; Metazoa - 2434; Fungi - 507; Plants - 1016; Viruses - 2; Other Eukaryotes - 1415 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      16953515..16961245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001344445.1 → NP_001330664.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    2. NM_001344446.1 → NP_001330665.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    3. NM_001344447.1 → NP_001330668.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    4. NM_001344448.1 → NP_001330669.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    5. NM_001344444.1 → NP_001318731.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    6. NM_001344449.1 → NP_001330666.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    7. NM_001344450.1 → NP_001330667.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins

    8. NM_001344451.1 → NP_001330670.1  SET domain protein 25 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBK4, A0A5S9YA69, A0A654G783
      Conserved Domains (1) summary
      cd19169
      Location:1237 → 1384
      SET_SETD1; SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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