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    H2BC6 H2B clustered histone 6 [ Homo sapiens (human) ]

    Gene ID: 8344, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2BC6provided by HGNC
    Official Full Name
    H2B clustered histone 6provided by HGNC
    Primary source
    HGNC:HGNC:4753
    See related
    Ensembl:ENSG00000274290 MIM:602805; AllianceGenome:HGNC:4753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2B.h; H2B/h; H2BC4; H2BC7; H2BC8; H2BFH; H2BC10; HIST1H2BE; dJ221C16.8
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H2BC6 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26183761..26184230)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26051896..26052365)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26183989..26184458)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26156285-26157036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17001 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26157790-26158541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24195 Neighboring gene Sharpr-MPRA regulatory region 13869 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26160799-26161550 Neighboring gene H1.4 linker histone, cluster member Neighboring gene H2BC6 antisense RNA 1 Neighboring gene H2B clustered histone 5 Neighboring gene LARP1 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26172075-26172967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24196 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26183023-26183752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24198 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26187941-26188566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24199 Neighboring gene H4 clustered histone 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24200 Neighboring gene H1.12 linker histone, cluster member, pseudogene

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of histone cluster 1, H2be (HIST1H2BE) in human B cells PubMed
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    histone H2B type 1-C/E/F/G/I
    Names
    H2B histone family, member H
    histone 1, H2be
    histone H2B.1 A
    histone H2B.h
    histone cluster 1 H2B family member e
    histone cluster 1, H2be

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003523.3NP_003514.2  histone H2B type 1-C/E/F/G/I

      See identical proteins and their annotated locations for NP_003514.2

      Status: REVIEWED

      Source sequence(s)
      AL353759
      Consensus CDS
      CCDS4588.1
      UniProtKB/Swiss-Prot
      P02278, P62807, Q3B872, Q4VB69, Q93078, Q93080
      UniProtKB/TrEMBL
      B2R4S9, Q0D2M2
      Related
      ENSP00000483237.2, ENST00000614097.3
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26183761..26184230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26051896..26052365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)