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    PER3 period circadian regulator 3 [ Homo sapiens (human) ]

    Gene ID: 8863, updated on 27-Nov-2024

    Summary

    Official Symbol
    PER3provided by HGNC
    Official Full Name
    period circadian regulator 3provided by HGNC
    Primary source
    HGNC:HGNC:8847
    See related
    Ensembl:ENSG00000049246 MIM:603427; AllianceGenome:HGNC:8847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GIG13; FASPS3
    Summary
    This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been linked to sleep disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 14.6), fat (RPKM 11.2) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PER3 in Genome Data Viewer
    Location:
    1p36.23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7784291..7845177)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7315337..7376224)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (7844351..7905237)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 185 Neighboring gene MPRA-validated peak40 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7830560-7831256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7912645-7913333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:7929285-7930484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7935645-7936144 Neighboring gene vesicle associated membrane protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chr1:7970949-7971450 Neighboring gene tRNA-undetermined (NNN) 4-1 Neighboring gene urotensin 2 Neighboring gene TNF receptor superfamily member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Advanced sleep phase syndrome 3
    MedGen: C4225169 OMIM: 616882 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of period homolog 3 (Drosophila, PER3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    period circadian protein homolog 3
    Names
    cell growth-inhibiting gene 13 protein
    circadian clock protein PERIOD 3
    period circadian clock 3
    period circadian protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046850.1 RefSeqGene

      Range
      4912..65798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001289861.2NP_001276790.1  period circadian protein homolog 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      Z98884
      Consensus CDS
      CCDS76097.1
      UniProtKB/TrEMBL
      A0A087WV69, A6H8X0
      Related
      ENSP00000479223.1, ENST00000614998.4
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:285373
      PAS_3; PAS fold
      pfam12114
      Location:10641179
      Period_C; Period protein 2/3C-terminal region
    2. NM_001289862.2NP_001276791.1  period circadian protein homolog 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      Z98884
      Consensus CDS
      CCDS72695.1
      UniProtKB/TrEMBL
      A6H8X0
      Related
      ENSP00000482093.1, ENST00000613533.4
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam05109
      Location:7561066
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12114
      Location:10831198
      Period_C; Period protein 2/3C-terminal region
    3. NM_001289863.3NP_001276792.1  period circadian protein homolog 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      Z98884
      UniProtKB/TrEMBL
      A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:285373
      PAS_3; PAS fold
      pfam12114
      Location:10571172
      Period_C; Period protein 2/3C-terminal region
    4. NM_001289864.3NP_001276793.1  period circadian protein homolog 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      Z98884
      UniProtKB/Swiss-Prot
      P56645
      Conserved Domains (1) summary
      pfam12114
      Location:763878
      Period_C; Period protein 2/3C-terminal region
    5. NM_001377275.1NP_001364204.1  period circadian protein homolog 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      Z98884
      Consensus CDS
      CCDS72695.1
      UniProtKB/TrEMBL
      A6H8X0
      Related
      ENSP00000366755.3, ENST00000377532.8
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam05109
      Location:7561066
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12114
      Location:10831198
      Period_C; Period protein 2/3C-terminal region
    6. NM_001377276.1NP_001364205.1  period circadian protein homolog 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      Z98884
      UniProtKB/TrEMBL
      A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam05109
      Location:7491058
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam12114
      Location:10751190
      Period_C; Period protein 2/3C-terminal region
    7. NM_016831.4NP_058515.1  period circadian protein homolog 3 isoform 4

      See identical proteins and their annotated locations for NP_058515.1

      Status: REVIEWED

      Source sequence(s)
      Z98884
      Consensus CDS
      CCDS89.1
      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5, A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:284376
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:10731186
      Period_C; Period protein 2/3C-terminal region
      cl25496
      Location:7481057
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      7784291..7845177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433449.1XP_047289405.1  period circadian protein homolog 3 isoform X8

    2. XM_047433435.1XP_047289391.1  period circadian protein homolog 3 isoform X2

    3. XM_047433457.1XP_047289413.1  period circadian protein homolog 3 isoform X12

    4. XM_047433442.1XP_047289398.1  period circadian protein homolog 3 isoform X5

    5. XM_047433459.1XP_047289415.1  period circadian protein homolog 3 isoform X13

    6. XM_047433453.1XP_047289409.1  period circadian protein homolog 3 isoform X10

    7. XM_047433437.1XP_047289393.1  period circadian protein homolog 3 isoform X3

    8. XM_047433440.1XP_047289396.1  period circadian protein homolog 3 isoform X4

    9. XM_047433473.1XP_047289429.1  period circadian protein homolog 3 isoform X15

    10. XM_047433454.1XP_047289410.1  period circadian protein homolog 3 isoform X11

      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5
      Related
      ENSP00000355031.2, ENST00000361923.2
    11. XM_047433434.1XP_047289390.1  period circadian protein homolog 3 isoform X1

    12. XM_047433446.1XP_047289402.1  period circadian protein homolog 3 isoform X7

    13. XM_047433455.1XP_047289411.1  period circadian protein homolog 3 isoform X11

      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5
    14. XM_047433436.1XP_047289392.1  period circadian protein homolog 3 isoform X2

    15. XM_047433443.1XP_047289399.1  period circadian protein homolog 3 isoform X5

    16. XM_047433466.1XP_047289422.1  period circadian protein homolog 3 isoform X13

    17. XM_047433447.1XP_047289403.1  period circadian protein homolog 3 isoform X7

    18. XM_047433438.1XP_047289394.1  period circadian protein homolog 3 isoform X3

    19. XM_047433451.1XP_047289407.1  period circadian protein homolog 3 isoform X9

    20. XM_005263524.5XP_005263581.1  period circadian protein homolog 3 isoform X6

      UniProtKB/TrEMBL
      A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:285373
      PAS_3; PAS fold
      pfam12114
      Location:10831192
      Period_C; Period protein 2/3C-terminal region
    21. XM_047433448.1XP_047289404.1  period circadian protein homolog 3 isoform X8

    22. XM_024450586.2XP_024306354.1  period circadian protein homolog 3 isoform X2

      UniProtKB/TrEMBL
      A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:10811194
      Period_C; Period protein 2/3C-terminal region
      cl25496
      Location:7561065
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    23. XM_047433456.1XP_047289412.1  period circadian protein homolog 3 isoform X12

    24. XM_024450587.2XP_024306355.1  period circadian protein homolog 3 isoform X5

      UniProtKB/TrEMBL
      A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:285377
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:10751188
      Period_C; Period protein 2/3C-terminal region
      cl25496
      Location:7491059
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    25. XM_047433458.1XP_047289414.1  period circadian protein homolog 3 isoform X13

    26. XM_017002723.3XP_016858212.1  period circadian protein homolog 3 isoform X3

      UniProtKB/TrEMBL
      A6H8X0
    27. XM_017002724.3XP_016858213.1  period circadian protein homolog 3 isoform X4

      UniProtKB/TrEMBL
      A6H8X0
    28. XM_047433468.1XP_047289424.1  period circadian protein homolog 3 isoform X14

    29. XM_017002726.3XP_016858215.1  period circadian protein homolog 3 isoform X9

      UniProtKB/TrEMBL
      A6H8X0
    30. XM_047433472.1XP_047289428.1  period circadian protein homolog 3 isoform X15

    31. XM_024450590.2XP_024306358.1  period circadian protein homolog 3 isoform X11

      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5, A6H8X0
      Conserved Domains (3) summary
      cd00130
      Location:284376
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam12114
      Location:10731186
      Period_C; Period protein 2/3C-terminal region
      cl25496
      Location:7481057
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    32. XM_047433439.1XP_047289395.1  period circadian protein homolog 3 isoform X2

    33. XM_047433445.1XP_047289401.1  period circadian protein homolog 3 isoform X6

    34. XM_047433444.1XP_047289400.1  period circadian protein homolog 3 isoform X5

    35. XM_047433441.1XP_047289397.1  period circadian protein homolog 3 isoform X4

    36. XM_047433452.1XP_047289408.1  period circadian protein homolog 3 isoform X9

    37. XM_047433474.1XP_047289430.1  period circadian protein homolog 3 isoform X16

    38. XM_047433475.1XP_047289431.1  period circadian protein homolog 3 isoform X17

    39. XM_017002729.2XP_016858218.2  period circadian protein homolog 3 isoform X18

    40. XM_047433476.1XP_047289432.1  period circadian protein homolog 3 isoform X19

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      7315337..7376224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339423.1XP_054195398.1  period circadian protein homolog 3 isoform X2

    2. XM_054339429.1XP_054195404.1  period circadian protein homolog 3 isoform X5

    3. XM_054339445.1XP_054195420.1  period circadian protein homolog 3 isoform X13

    4. XM_054339434.1XP_054195409.1  period circadian protein homolog 3 isoform X7

    5. XM_054339424.1XP_054195399.1  period circadian protein homolog 3 isoform X3

    6. XM_054339437.1XP_054195412.1  period circadian protein homolog 3 isoform X9

    7. XM_054339432.1XP_054195407.1  period circadian protein homolog 3 isoform X6

    8. XM_054339435.1XP_054195410.1  period circadian protein homolog 3 isoform X8

    9. XM_054339422.1XP_054195397.1  period circadian protein homolog 3 isoform X2

    10. XM_054339443.1XP_054195418.1  period circadian protein homolog 3 isoform X12

    11. XM_054339431.1XP_054195406.1  period circadian protein homolog 3 isoform X5

    12. XM_054339444.1XP_054195419.1  period circadian protein homolog 3 isoform X13

    13. XM_054339425.1XP_054195400.1  period circadian protein homolog 3 isoform X3

    14. XM_054339427.1XP_054195402.1  period circadian protein homolog 3 isoform X4

    15. XM_054339446.1XP_054195421.1  period circadian protein homolog 3 isoform X14

    16. XM_054339436.1XP_054195411.1  period circadian protein homolog 3 isoform X9

    17. XM_054339441.1XP_054195416.1  period circadian protein homolog 3 isoform X11

      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5
    18. XM_054339439.1XP_054195414.1  period circadian protein homolog 3 isoform X10

    19. XM_054339421.1XP_054195396.1  period circadian protein homolog 3 isoform X1

    20. XM_054339440.1XP_054195415.1  period circadian protein homolog 3 isoform X7

    21. XM_054339442.1XP_054195417.1  period circadian protein homolog 3 isoform X11

      UniProtKB/Swiss-Prot
      P56645, Q5H8X4, Q5H8X5, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8
      UniProtKB/TrEMBL
      A2I2N5
    22. XM_054339426.1XP_054195401.1  period circadian protein homolog 3 isoform X2

    23. XM_054339447.1XP_054195422.1  period circadian protein homolog 3 isoform X15

    24. XM_054339433.1XP_054195408.1  period circadian protein homolog 3 isoform X6

    25. XM_054339430.1XP_054195405.1  period circadian protein homolog 3 isoform X5

    26. XM_054339428.1XP_054195403.1  period circadian protein homolog 3 isoform X4

    27. XM_054339438.1XP_054195413.1  period circadian protein homolog 3 isoform X9

    28. XM_054339448.1XP_054195423.1  period circadian protein homolog 3 isoform X16

    29. XM_054339449.1XP_054195424.1  period circadian protein homolog 3 isoform X17

    30. XM_054339450.1XP_054195425.1  period circadian protein homolog 3 isoform X18

    31. XM_054339451.1XP_054195426.1  period circadian protein homolog 3 isoform X19