ACBP3 acyl-CoA-binding domain 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACBP3
Official Full Name: acyl-CoA-binding domain 3
Primary source: TAIR:AT4G24230
Locus tag: AT4G24230
See related: Araport:AT4G24230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: acyl-CoA-binding domain 3; T22A6.60; T22A6_60
Summary: acyl-CoA-binding protein ACBP3. Localized extracellularly in transiently expressed tobacco BY-2 cells and onion epidermal cells. Binds arachidonyl-CoA with high affinity. Microarray data shows up-regulation of many biotic- and abiotic-stress-related genes in an ACBP3 OE-1 in comparison to wild type.
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Genomic context

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See ACBP3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (12566631..12568866, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A promoter polymorphism defines distinct roles in anther development for Col-0 and Ler-0 alleles of Arabidopsis ACYL-COA BINDING PROTEIN3.
Title: A promoter polymorphism defines distinct roles in anther development for Col-0 and Ler-0 alleles of Arabidopsis ACYL-COA BINDING PROTEIN3.
ACBP3 participates in plant response to hypoxia by modulating VLCFA metabolism.
Title: Arabidopsis acyl-CoA-binding protein ACBP3 participates in plant response to hypoxia by modulating very-long-chain fatty acid metabolism.
Three cis-responsive elements (Dof, GT-1, and the S-box) in the 5'-flanking region of ACBP3 are proven functional in the regulation of ACBP3.
Title: The gene encoding Arabidopsis acyl-CoA-binding protein 3 is pathogen inducible and subject to circadian regulation.
The enhanced pathogenesis-related gene expression and P. syringae DC3000 resistance in the ACBP3-overexpressors are dependent on the NPR1-mediated, but not the COI1-mediated, signaling pathway.
Title: Overexpression of Arabidopsis ACBP3 enhances NPR1-dependent plant resistance to Pseudomonas syringe pv tomato DC3000.
ACBP3 is an important regulator of the ATG8- phosphatidylethanolamine (PE) complex via its interaction with PE.
Title: The Arabidopsis thaliana ACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability.
Investigations on ACBP3 reported here show its upregulation upon dark treatment and in senescing rosettes.
Title: Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence.
Acyl-CoA-binding protein3 (ACBP3) localizes extracellularly and the affinities of the acyl-CoA-binding domain in ACBP3 are investigated by in vitro binding assays. [ACBP3]
Title: Arabidopsis ACBP3 is an extracellularly targeted acyl-CoA-binding protein.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001084970.1

Supported by ESTs:

NM_001084971.1

Supported by ESTs:

NM_001084972.2

Supported by ESTs:

NM_001125569.1

Supported by ESTs:

NM_118556.4

Supported by ESTs:

NM_179101.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within defense response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to absence of light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl-CoA-binding domain 3

NP_001078439.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 2819 Blast hits to 2269 proteins in 433 species: Archae - 5; Bacteria - 548; Metazoa - 996; Fungi - 151; Plants - 324; Viruses - 30; Other Eukaryotes - 765 (source: NCBI BLink).

NP_001078440.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 2822 Blast hits to 2272 proteins in 435 species: Archae - 5; Bacteria - 551; Metazoa - 996; Fungi - 151; Plants - 324; Viruses - 30; Other Eukaryotes - 765 (source: NCBI BLink).

NP_001078441.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 2819 Blast hits to 2269 proteins in 433 species: Archae - 5; Bacteria - 548; Metazoa - 996; Fungi - 151; Plants - 324; Viruses - 30; Other Eukaryotes - 765 (source: NCBI BLink).

NP_001119041.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_194154.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 2819 Blast hits to 2269 proteins in 433 species: Archae - 5; Bacteria - 548; Metazoa - 996; Fungi - 151; Plants - 324; Viruses - 30; Other Eukaryotes - 765 (source: NCBI BLink).

NP_849432.1

acyl-CoA-binding domain 3 (ACBP3); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: fatty acid transport; LOCATED IN: extracellular region; EXPRESSED IN: 6 plant structures; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 2 (TAIR:AT4G27780.1); Has 2815 Blast hits to 2273 proteins in 432 species: Archae - 7; Bacteria - 546; Metazoa - 989; Fungi - 148; Plants - 324; Viruses - 30; Other Eukaryotes - 771 (source: NCBI BLink).