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    uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824612, updated on 18-Sep-2024

    Summary

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    Official Full Name
    uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS)
    Primary source
    TAIR:AT3G54470
    Locus tag
    AT3G54470
    See related
    Araport:AT3G54470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Summary
    encodes the bi-functional orotate phosphoribosyltransferase/orotidine-5'-phosphate decarboxylase catalyzing the fifth and sixth step in the de novo pyrimidine ribonucleotide biosynthesis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (20168005..20170320, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily protein Neighboring gene SNF2 domain-containing protein / helicase domain-containing protein / F-box family protein Neighboring gene SKP1/ASK-interacting protein 5 Neighboring gene ncRNA Neighboring gene RNA polymerase II fifth largest subunit, E

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterospecific cloning of Arabidopsis thaliana cDNAs by direct complementation of pyrimidine auxotrophic mutants of Saccharomyces cerevisiae. I. Cloning and sequence analysis of two cDNAs catalysing the second, fifth and sixth steps of the de novo pyrimidine biosynthesis pathway. Nasr F, et al. Mol Gen Genet, 1994 Jul 8. PMID 8041358
    2. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
    3. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_148875.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables orotate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotate phosphoribosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables orotidine-5'-phosphate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables orotidine-5'-phosphate decarboxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS)
    NP_680130.1
    • uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS); FUNCTIONS IN: orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity; INVOLVED IN: response to cadmium ion, cellular response to phosphate starvation, pyrimidine ribonucleotide biosynthetic process, nucleoside metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Orotidine 5'-phosphate decarboxylase, subfamily 1, core (InterPro:IPR014732), Orotidine 5'-phosphate decarboxylase, active site (InterPro:IPR018089), Ribulose-phosphate binding barrel (InterPro:IPR011060), Phosphoribosyltransferase (InterPro:IPR000836), Orotate phosphoribosyl transferase (InterPro:IPR004467), Orotidine 5'-phosphate decarboxylase, core (InterPro:IPR001754); Has 9174 Blast hits to 9124 proteins in 2964 species: Archae - 386; Bacteria - 5538; Metazoa - 208; Fungi - 955; Plants - 89; Viruses - 3; Other Eukaryotes - 1995 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20168005..20170320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_148875.5 → NP_680130.1  uridine 5'-monophosphate synthase / UMP synthase (PYRE-F) (UMPS) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_680130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42586, Q9M1I0
      UniProtKB/TrEMBL
      A0A178V9W3, A0A5S9XKR6, A0A654FHX0
      Conserved Domains (2) summary
      pfam00215
      Location:243 → 462
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
      cl00309
      Location:7 → 199
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42586.2

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