LOS4 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: LOS4
Official Full Name: P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source: TAIR:AT3G53110
Locus tag: AT3G53110
See related: Araport:AT3G53110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4
Summary: Encodes a putative DEAD-Box RNA Helicase and has RNA-dependent ATPase activity. Mutant is Sensitive to chilling stress and heat stress. Germination of the mutant is inhibited by ABA. LOS4 may be involved in temperature sensing. Is enriched in the nuclear envelope and also located in the cytoplasm. LOS4 is involved in export of poly A RNA.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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CRYOPHYTE/LOS4 RNA helicase plays an important role in mRNA export, plant development, and stress responses. [LOS4]
Title: A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_115171.3

Function	Evidence Code	Pubs
enables ATP-dependent activity, acting on RNA	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

Preferred Names: P-loop containing nucleoside triphosphate hydrolases superfamily protein

NP_190879.1

LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 4 (LOS4); FUNCTIONS IN: RNA helicase activity, RNA-dependent ATPase activity, ATP-dependent helicase activity; INVOLVED IN: poly(A)+ mRNA export from nucleus, response to cold, response to heat, response to abscisic acid stimulus; LOCATED IN: nuclear envelope, plasma membrane, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: eukaryotic initiation factor 4A-III (TAIR:AT3G19760.1); Has 40925 Blast hits to 40635 proteins in 3033 species: Archae - 702; Bacteria - 21081; Metazoa - 5720; Fungi - 4311; Plants - 2419; Viruses - 28; Other Eukaryotes - 6664 (source: NCBI BLink).

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