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    NEK4 NIMA-related kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825503, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NEK4
    Official Full Name
    NIMA-related kinase 4
    Primary source
    TAIR:AT3G63280
    Locus tag
    AT3G63280
    See related
    Araport:AT3G63280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNEK4; MAA21.6; NIMA-related kinase 4; NIMA-RELATED KINASE4
    Summary
    Encodes AtNek4, a member of the NIMA-related serine/threonine kinases (Neks) that have been linked to cell-cycle regulation in fungi and mammals. Plant Neks might be involved in plant development processes.
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    Genomic context

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    See NEK4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (23377976..23381590)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein Neighboring gene nuclease Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene FORKED 1 Neighboring gene Bax inhibitor-1 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana. Motose H, et al. Plant J, 2011 Sep. PMID 21605211
    2. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEK6 forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
      Title: NIMA-related kinases 6, 4, and 5 interact with each other to regulate microtubule organization during epidermal cell expansion in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125427.1
    NM_001340197.1
    NM_001340198.1
    NM_116193.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NIMA-related kinase 4
    NP_001118899.1
    • NIMA-related kinase 4 (NEK4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 2 (TAIR:AT3G04810.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_191887.2
    • NIMA-related kinase 4 (NEK4); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: NIMA-related kinase 2 (TAIR:AT3G04810.2); Has 126311 Blast hits to 124068 proteins in 4177 species: Archae - 117; Bacteria - 14403; Metazoa - 46720; Fungi - 12754; Plants - 30797; Viruses - 521; Other Eukaryotes - 20999 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23377976..23381590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116193.5 → NP_191887.2  NIMA-related kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191887.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXT4, Q9M1W2
      UniProtKB/TrEMBL
      A0A7G2F030
      Conserved Domains (2) summary
      smart00220
      Location:4 → 256
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08215
      Location:3 → 258
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    2. NM_001340197.1 → NP_001326587.1  NIMA-related kinase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXT4, Q9M1W2
      UniProtKB/TrEMBL
      A0A7G2F030
      Conserved Domains (2) summary
      smart00220
      Location:4 → 256
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08215
      Location:3 → 258
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    3. NM_001125427.1 → NP_001118899.1  NIMA-related kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118899.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXT4, Q9M1W2
      UniProtKB/TrEMBL
      A0A7G2F030
      Conserved Domains (2) summary
      smart00220
      Location:4 → 256
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08215
      Location:3 → 258
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase

    4. NM_001340198.1 → NP_001326588.1  NIMA-related kinase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPR2, A0A5S9XP22, A0A654FKB1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RXT4.1

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