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    IBR5 indole-3-butyric acid response 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814997, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IBR5
    Official Full Name
    indole-3-butyric acid response 5
    Primary source
    TAIR:AT2G04550
    Locus tag
    AT2G04550
    See related
    Araport:AT2G04550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DSPTP1E; DUAL SPECIFICITY PROTEIN PHOSPHATASE 1E; indole-3-butyric acid response 5; T1O3.4; T1O3_4
    Summary
    Encodes a protein phosphatase that interacts with MPK12, but not with other MAP kinases. It can dephosphorylate a dually phosphorylated MPK12 in vitro and can inactivate MPK12 in vivo. ibr5 mutants have reduced sensitivity to auxin and abscisic acid. IBR5 promotes auxin responses, including auxin-inducible transcription, differently than the TIR1 auxin receptor and without destabilizing Aux/IAA repressor proteins.
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    Genomic context

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    See IBR5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (1588193..1590166)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Beta-ketoacyl synthase Neighboring gene miscRNA Neighboring gene transferases, transferring glycosyl groups Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Tinkerbell (Tink) Mutation Identifies the Dual-Specificity MAPK Phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a Novel Regulator of Organ Size in Arabidopsis. Johnson KL, et al. PLoS One, 2015. PMID 26147117, Free PMC Article
    2. Arabidopsis iba response5 suppressors separate responses to various hormones. Strader LC, et al. Genetics, 2008 Dec. PMID 18832358, Free PMC Article
    3. The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation. Strader LC, et al. BMC Plant Biol, 2008 Apr 18. PMID 18423007, Free PMC Article
    4. IBR5, a dual-specificity phosphatase-like protein modulating auxin and abscisic acid responsiveness in Arabidopsis. Monroe-Augustus M, et al. Plant Cell, 2003 Dec. PMID 14630970, Free PMC Article
    5. IBR5 Regulates Leaf Serrations Development via Modulation of the Expression of PIN1. Kong X, et al. Int J Mol Sci, 2019 Sep 9. PMID 31505781, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IBR5 is essential for the establishment of PIN-FORMED 1 (PIN1)-directed auxin maxima at the tips of leaf serration, which is vital for the elaborated regulation during its formation.
      Title: IBR5 Regulates Leaf Serrations Development via Modulation of the Expression of PIN1.
    2. IBR5 encodes a putative dual-specificity protein phosphatase. The accumulation of CHS3 protein at chilling temperatures is inhibited by the IBR5 mutation.
      Title: IBR5 Modulates Temperature-Dependent, R Protein CHS3-Mediated Defense Responses in Arabidopsis.
    3. Microarray analysis of tink/ibr5-6 mutants identified a likely role for this phosphatase in male gametophyte development. IBR5 may influence the size and shape of petals through auxin and TCP growth regulatory pathways.
      Title: The Tinkerbell (Tink) Mutation Identifies the Dual-Specificity MAPK Phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a Novel Regulator of Organ Size in Arabidopsis.
    4. IBR5 is a MAPK phosphatase that dephosphorylates and inactivates MPK12.
      Title: Arabidopsis mitogen-activated protein kinase MPK12 interacts with the MAPK phosphatase IBR5 and regulates auxin signaling.
    5. Arabidopsis iba response5 suppressors separate responses to various hormones
      Title: Arabidopsis iba response5 suppressors separate responses to various hormones.
    6. Data suggest that IBR5 is a phosphatase that promotes auxin responses, including auxin-inducible transcription, differently than the TIR1 auxin receptor and without destabilizing Aux/IAA repressor proteins.
      Title: The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation.
    7. IBR5 is an apparent MAP kinase phosphatase. ibr5 mutants display reduced responses to auxin and abscisic acid (ABA).
      Title: IBR5, a dual-specificity phosphatase-like protein modulating auxin and abscisic acid responsiveness in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_126486.6
    NM_201689.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of rate of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    indole-3-butyric acid response 5
    NP_178534.2
    • indole-3-butyric acid response 5 (IBR5); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973418.2
    • indole-3-butyric acid response 5 (IBR5); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 3359 Blast hits to 3359 proteins in 285 species: Archae - 9; Bacteria - 32; Metazoa - 1975; Fungi - 228; Plants - 239; Viruses - 200; Other Eukaryotes - 676 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1588193..1590166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126486.6 → NP_178534.2  indole-3-butyric acid response 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178534.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EC68, Q84JU4, Q9SJB6
      UniProtKB/TrEMBL
      A0A178VVJ8, A0A7G2EB95
      Conserved Domains (1) summary
      cd18534
      Location:50 → 179
      DSP_plant_IBR5-like; dual specificity phosphatase domain of plant IBR5-like protein phosphatases

    2. NM_201689.3 → NP_973418.2  indole-3-butyric acid response 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973418.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JU4
      Conserved Domains (1) summary
      cd00127
      Location:50 → 170
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JU4.1

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