GCR1 G-protein-coupled receptor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GCR1
Official Full Name: G-protein-coupled receptor 1
Primary source: TAIR:AT1G48270
Locus tag: AT1G48270
See related: Araport:AT1G48270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F11A17.17; F11A17_17; G-protein-coupled receptor 1
Summary: encodes a protein similar to G-coupled receptor with 7 transmembrane regions. Overexpression studies suggest this gene is involved in dormancy and flowering. Reduction of expression results in decreased sensitivity to cytokinin.
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Genomic context

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See GCR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (17827953..17830420, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

provide compelling genetic evidence to revisit the role of GCR1 in G-protein signalling
Title: G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.
GCR1 and GPA1 are involved in N-acyl-homoserine lactones -mediated elongation of Arabidopsis roots.
Title: The GCR1 and GPA1 participate in promotion of Arabidopsis primary root elongation induced by N-acyl-homoserine lactones, the bacterial quorum-sensing signals.
GCR1 plays a positive role in gibberellin and brassinosteroid regulated seed germination. Unlike a typical 7TM receptor, it acts independently of the heterotrimeric G-protein.
Title: GCR1 can act independently of heterotrimeric G-protein in response to brassinosteroids and gibberellins in Arabidopsis seed germination.
GCR1 may act as a negative regulator of G protein alpha subunit GPA1-mediated abscisic acid responses in guard cells [GCR1]
Title: The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling.
G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
Title: G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001333320.1

Supported by ESTs:

NM_103724.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-phenylalanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blue light signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gibberellic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inositol trisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokinin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tyrosine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: G-protein-coupled receptor 1

NP_175261.1

G-protein-coupled receptor 1 (GCR1); FUNCTIONS IN: G-protein coupled receptor activity; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: G-protein-coupled receptor, GCR1 putative (InterPro:IPR022340), GPCR, family 2-like (InterPro:IPR017981), GCR1-cAMP receptor (InterPro:IPR022343); Has 592 Blast hits to 590 proteins in 111 species: Archae - 0; Bacteria - 0; Metazoa - 324; Fungi - 88; Plants - 42; Viruses - 0; Other Eukaryotes - 138 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

17827953..17830420 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103724.2 → NP_175261.1 G-protein-coupled receptor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175261.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04214, O04714, Q8LPG0

UniProtKB/TrEMBL

A0A178WGM3

Conserved Domains (2) summary

cd14964
Location:48 → 70

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:26 → 272

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001333320.1 → NP_001321802.1 G-protein-coupled receptor 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O04214, O04714, Q8LPG0

UniProtKB/TrEMBL

A0A178WGM3

Conserved Domains (2) summary

cd14964
Location:48 → 70

7tm_GPCRs; TM helix 2 [structural motif]

cl28897
Location:26 → 272

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily