Sec23ip Sec23 interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec23ipprovided by MGI
Official Full Name: Sec23 interacting proteinprovided by MGI
Primary source: MGI:MGI:2450915
See related: Ensembl:ENSMUSG00000055319 AllianceGenome:MGI:2450915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p125; D7Ertd373e
Summary: Predicted to enable phospholipase activity. Acts upstream of or within acrosome assembly and single fertilization. Located in cis-Golgi network; endoplasmic reticulum exit site; and perinuclear endoplasmic reticulum. Orthologous to human SEC23IP (SEC23 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 24.2), thymus adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 70.51 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (128346667..128386560)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (128744862..128784836)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

involved in cholesterol trafficking to supply cholesterol for acute steroidogenesis through its interactions with 14-3-3gamma
Title: Identification of Sec23ip, Part of 14-3-3γ Protein Network, as a Regulator of Acute Steroidogenesis in MA-10 Leydig Cells.
These results suggest that p125/Sec23-interacting protein plays an important role in spermiogenesis.
Title: p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH127090 (e-PCR)
- UniSTS:167514

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SEC23-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029982.3 → NP_001025153.2 SEC23-interacting protein isoform 1

See identical proteins and their annotated locations for NP_001025153.2

Status: VALIDATED

Source sequence(s)

AC136741

Consensus CDS

CCDS21900.1

UniProtKB/TrEMBL

G3X928, Q4G0C0

Related

ENSMUSP00000035610.9, ENSMUST00000042942.10

Conserved Domains (3) summary

smart00454
Location:649 → 700

SAM; Sterile alpha motif

pfam02862
Location:780 → 986

DDHD; DDHD domain

cl15755
Location:634 → 702

SAM_superfamily; SAM (Sterile alpha motif )
NM_001420513.1 → NP_001407442.1 SEC23-interacting protein isoform 2

Status: VALIDATED

Source sequence(s)

AC136741

UniProtKB/TrEMBL

Q4G0C0
NM_001420514.1 → NP_001407443.1 SEC23-interacting protein isoform 3

Status: VALIDATED

Source sequence(s)

AC136741

UniProtKB/TrEMBL

A0AUN0