Hmgn5 high-mobility group nucleosome binding domain 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmgn5provided by MGI
Official Full Name: high-mobility group nucleosome binding domain 5provided by MGI
Primary source: MGI:MGI:1355295
See related: Ensembl:ENSMUSG00000031245 AllianceGenome:MGI:1355295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nsbp1; GARP45; NBP-45
Summary: Enables chromatin binding activity. Acts upstream of or within chromatin organization; glutathione metabolic process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; gut gland; and hemolymphoid system gland. Orthologous to human HMGN5 (high mobility group nucleosome binding domain 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 39.8), CNS E11.5 (RPKM 28.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 47.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (108048143..108056986, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (109004537..109013380, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis.
Title: HMGN5 Escorts Oncogenic STAT3 Signaling by Regulating the Chromatin Landscape in Breast Cancer Tumorigenesis.
HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
Title: HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2.
Title: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction.
Title: Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.
HMGN5 overexpression induces neurite outgrowth.
Title: Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.
functional loss of HMGN5 leads to changes in transcription of Gpx6 and Hk1 that alter glutathione metabolism.
Title: Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.
Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities.
Title: High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
Downregulation of NSBP1 reduced the cancer growth rate, whereas tumourigenicity was not influenced.
Title: Downregulation of the nucleosome-binding protein 1 (NSBP1) gene can inhibit the in vitro and in vivo proliferation of prostate cancer cells.
NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones.
Title: The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nsbp1 (e-PCR), detects polymorphism
- UniSTS:224163

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosomal DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: high mobility group nucleosome-binding domain-containing protein 5

Names: nucleosome binding protein 1; nucleosome binding protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016710.2 → NP_057919.2 high mobility group nucleosome-binding domain-containing protein 5

Status: VALIDATED

Source sequence(s)

AK146755, BY279928, BY387611

Consensus CDS

CCDS41101.1

UniProtKB/Swiss-Prot

O88832, Q3V272, Q8VC71, Q9CUW1, Q9JL35

Related

ENSMUSP00000033597.9, ENSMUST00000033597.9

Conserved Domains (1) summary

pfam01101
Location:2 → 93

HMG14_17; HMG14 and HMG17