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    TAB3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 257397, updated on 3-Dec-2024

    Summary

    Official Symbol
    TAB3provided by HGNC
    Official Full Name
    TGF-beta activated kinase 1 (MAP3K7) binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:30681
    See related
    Ensembl:ENSG00000157625 MIM:300480; AllianceGenome:HGNC:30681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NAP1; MAP3K7IP3
    Summary
    The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 6.3), endometrium (RPKM 5.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TAB3 in Genome Data Viewer
    Location:
    Xp21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (30827442..30889254, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (30425653..30487452, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (30845559..30907371, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:30771431-30772154 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:30813295-30813854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20726 Neighboring gene myoneurin pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29510 Neighboring gene GK antisense RNA 1 Neighboring gene TAB3 antisense RNA 1 Neighboring gene glycerol kinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29513 Neighboring gene Sharpr-MPRA regulatory region 11226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29516 Neighboring gene Sharpr-MPRA regulatory region 5644 Neighboring gene ferritin heavy chain like 17 Neighboring gene dystrophin Neighboring gene RNA, U6 small nuclear 894, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr The ability of HIV-1 Vpr to activate NF-kappaB or activator protein 1-dependent luciferase expression requires TAK1, TRAF6, or TAB3 in cells PubMed
    capsid gag The TAK1 kinase complex (TAK1/TAB2/TAB3) contributes to capsid-specific restriction mediated by TRIM5alpha. TRIM5alpha activates TAK1 autophosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC45404

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
    Names
    NF-kappa-B-activating protein 1
    NFkB activating protein 1
    TAB-3
    TAK1-binding protein 3
    TGF-beta activated kinase 1 and MAP3K7 binding protein 3
    TGF-beta-activated kinase 1-binding protein 3
    mitogen-activated protein kinase kinase kinase 7 interacting protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012845.2 RefSeqGene

      Range
      5141..66953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001399870.1NP_001386799.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043
      UniProtKB/TrEMBL
      Q5JPK0
    2. NM_001399872.1NP_001386801.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043
      Consensus CDS
      CCDS94584.1
      UniProtKB/TrEMBL
      F6SS63
      Related
      ENSP00000368214.2, ENST00000378932.6
    3. NM_001399873.1NP_001386802.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043
      UniProtKB/TrEMBL
      Q5JPK0
    4. NM_152787.5NP_690000.3  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_690000.3

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, AK096786, BC032526, DA494641
      Consensus CDS
      CCDS14226.1
      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8
      UniProtKB/TrEMBL
      Q5JPK0
      Related
      ENSP00000288422.4, ENST00000288422.4
      Conserved Domains (4) summary
      smart00547
      Location:687709
      ZnF_RBZ; Zinc finger domain
      PRK10263
      Location:245345
      PRK10263; DNA translocase FtsK; Provisional
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      sd00029
      Location:687706
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RNA

    1. NR_174361.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043
    2. NR_174362.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC108359, AC117405, KF459043

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      30827442..30889254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441986.1XP_047297942.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8
      UniProtKB/TrEMBL
      Q5JPK0
    2. XM_017029400.2XP_016884889.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      Q5JPK0
      Conserved Domains (3) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam03153
      Location:122291
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam13900
      Location:634681
      GVQW; Putative domain of unknown function
    3. XM_047441987.1XP_047297943.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

      UniProtKB/TrEMBL
      Q5JPK0
    4. XM_011545488.3XP_011543790.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      F6SS63
      Conserved Domains (2) summary
      cd14362
      Location:950
      CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
      pfam03153
      Location:122291
      TFIIA; Transcription factor IIA, alpha/beta subunit
    5. XM_017029402.2XP_016884891.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      F6SS63
      Related
      ENSP00000433193.1, ENST00000467136.5

    RNA

    1. XR_950433.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      30425653..30487452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326818.1XP_054182793.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2

      UniProtKB/Swiss-Prot
      A6NDD9, Q6VQR0, Q8N5C8
      UniProtKB/TrEMBL
      Q5JPK0
    2. XM_054326817.1XP_054182792.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1

      UniProtKB/TrEMBL
      Q5JPK0
    3. XM_054326819.1XP_054182794.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X3

      UniProtKB/TrEMBL
      Q5JPK0
    4. XM_054326820.1XP_054182795.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      F6SS63
    5. XM_054326821.1XP_054182796.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X5

      UniProtKB/TrEMBL
      F6SS63

    RNA

    1. XR_008485476.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198312.1: Suppressed sequence

      Description
      NM_198312.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.