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    Bex6 brain expressed family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 328660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bex6provided by MGI
    Official Full Name
    brain expressed family member 6provided by MGI
    Primary source
    MGI:MGI:3588247
    See related
    Ensembl:ENSMUSG00000075269 AllianceGenome:MGI:3588247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B020003O03Rik
    Summary
    Predicted to enable alpha-tubulin binding activity and histone deacetylase binding activity. Predicted to be involved in several processes, including chromosome segregation; negative regulation of tubulin deacetylation; and regulation of cell migration. Located in cytoplasm. Is expressed in alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human BEX4 (brain expressed X-linked 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Bex6 in Genome Data Viewer
    Location:
    16 B2; 16 22.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31998618..32005762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32179800..32186944)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene centrosomal protein 19 Neighboring gene STARR-positive B cell enhancer ABC_E4165 Neighboring gene STARR-seq mESC enhancer starr_40643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32130316-32130510 Neighboring gene negative regulator of reactive oxygen species Neighboring gene STARR-positive B cell enhancer ABC_E7441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177054-32177400 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32177409-32177592 Neighboring gene STARR-seq mESC enhancer starr_40648 Neighboring gene STARR-seq mESC enhancer starr_40649 Neighboring gene F-box protein 45 Neighboring gene STARR-positive B cell enhancer ABC_E10901 Neighboring gene predicted gene, 25848 Neighboring gene WD repeat domain 53

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of Bex protein in the mouse brain and olfactory system. Koo JH, et al. J Comp Neurol, 2005 Jun 20. PMID 15861462
    2. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, et al. Gene, 2005 Aug 29. PMID 15958283
    3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein BEX6
    Names
    brain expressed gene 6
    brain expressed, X-linked 6
    brain-expressed X-linked protein 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033539.2 → NP_001028711.1  protein BEX6

      See identical proteins and their annotated locations for NP_001028711.1

      Status: PROVISIONAL

      Source sequence(s)
      AY833559
      Consensus CDS
      CCDS28116.1
      UniProtKB/Swiss-Prot
      A2RSJ0, Q3TZW7
      Related
      ENSMUSP00000156333.2, ENSMUST00000231941.2
      Conserved Domains (1) summary
      pfam04538
      Location:37 → 108
      BEX; Brain expressed X-linked like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      31998618..32005762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TZW7.1 GenPept UniProtKB/Swiss-Prot:Q3TZW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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