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    Qrich2 glutamine rich 2 [ Mus musculus (house mouse) ]

    Gene ID: 217341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qrich2provided by MGI
    Official Full Name
    glutamine rich 2provided by MGI
    Primary source
    MGI:MGI:2684912
    See related
    Ensembl:ENSMUSG00000070331 AllianceGenome:MGI:2684912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm66
    Summary
    Involved in cell projection assembly; flagellated sperm motility; and negative regulation of ubiquitin-dependent protein catabolic process. Located in cytoplasm; nucleus; and sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 35. Orthologous to human QRICH2 (glutamine rich 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 124.1) See more
    Orthologs
    human all
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    Genomic context

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    See Qrich2 in Genome Data Viewer
    Location:
    11 E2; 11 81.3 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116332149..116357092, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116441323..116466266, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 157 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:116255636-116255937 Neighboring gene STARR-positive B cell enhancer ABC_E9382 Neighboring gene STARR-positive B cell enhancer ABC_E8472 Neighboring gene STARR-positive B cell enhancer ABC_E5300 Neighboring gene STARR-positive B cell enhancer ABC_E10733 Neighboring gene STARR-seq mESC enhancer starr_31202 Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116351868-116352051 Neighboring gene ribosomal protein L36, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability. Zhang G, et al. Reprod Biol, 2024 Jun. PMID 38772286
    2. Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm. Zhang G, et al. Cell Mol Life Sci, 2024 Apr 10. PMID 38597976, Free PMC Article
    3. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development. Zhang G, et al. Hum Mol Genet, 2021 Dec 27. PMID 34415320
    4. Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella. Shen Y, et al. Nat Commun, 2019 Jan 25. PMID 30683861, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability.
      Title: A Key regulatory protein QRICH2 governing sperm function with profound antioxidant properties, enhancing sperm viability.
    2. Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm.
      Title: Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm.
    3. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
      Title: Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
    4. The findings strongly suggest that the genetic mutations of QRICH2 can lead to male infertility with multiple morphological abnormalities of the flagella, and that QRICH2 is essential for sperm flagellar formation.
      Title: Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamine-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033267.3 → NP_001028439.2  glutamine-rich protein 2

      Status: VALIDATED

      Source sequence(s)
      AL645851, AL645861
      Consensus CDS
      CCDS25667.1
      UniProtKB/TrEMBL
      A0A140LIY9
      Related
      ENSMUSP00000147009.2, ENSMUST00000208602.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116332149..116357092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533105.4 → XP_006533168.2  glutamine-rich protein 2 isoform X7

      Conserved Domains (4) summary
      PHA03378
      Location:1135 → 1404
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1517 → 1912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam03157
      Location:512 → 1111
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1763 → 1942
      DUF4795; Domain of unknown function (DUF4795)

    2. XM_011248958.3 → XP_011247260.1  glutamine-rich protein 2 isoform X6

      Conserved Domains (4) summary
      PHA03378
      Location:1173 → 1442
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1555 → 1950
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam03157
      Location:550 → 1149
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1801 → 1980
      DUF4795; Domain of unknown function (DUF4795)

    3. XM_011248957.3 → XP_011247259.1  glutamine-rich protein 2 isoform X5

      Conserved Domains (4) summary
      PHA03378
      Location:1195 → 1464
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1577 → 1972
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam03157
      Location:572 → 1171
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1823 → 2002
      DUF4795; Domain of unknown function (DUF4795)

    4. XM_011248956.3 → XP_011247258.1  glutamine-rich protein 2 isoform X4

      See identical proteins and their annotated locations for XP_011247258.1

      Conserved Domains (5) summary
      PHA03378
      Location:1205 → 1474
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1587 → 1982
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02169
      Location:95 → 237
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03157
      Location:594 → 1181
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1833 → 2012
      DUF4795; Domain of unknown function (DUF4795)

    5. XM_011248955.3 → XP_011247257.1  glutamine-rich protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011247257.1

      Conserved Domains (5) summary
      PHA03378
      Location:1205 → 1474
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1587 → 1982
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02169
      Location:95 → 237
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03157
      Location:594 → 1181
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1833 → 2012
      DUF4795; Domain of unknown function (DUF4795)

    6. XM_017314492.2 → XP_017169981.1  glutamine-rich protein 2 isoform X3

      Conserved Domains (5) summary
      PHA03378
      Location:1205 → 1474
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1587 → 1982
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02169
      Location:95 → 237
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03157
      Location:592 → 1213
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1833 → 2012
      DUF4795; Domain of unknown function (DUF4795)

    7. XM_011248959.2 → XP_011247261.1  glutamine-rich protein 2 isoform X9

      Conserved Domains (4) summary
      PHA03378
      Location:922 → 1191
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1304 → 1699
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam03157
      Location:299 → 887
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1550 → 1729
      DUF4795; Domain of unknown function (DUF4795)

    8. XM_017314493.2 → XP_017169982.1  glutamine-rich protein 2 isoform X8

      Conserved Domains (5) summary
      PHA03378
      Location:1215 → 1484
      PHA03378; EBNA-3B; Provisional
      COG0419
      Location:1597 → 1992
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02169
      Location:95 → 237
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam03157
      Location:592 → 1191
      Glutenin_hmw; High molecular weight glutenin subunit
      pfam16043
      Location:1843 → 2022
      DUF4795; Domain of unknown function (DUF4795)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V2A7.1 GenPept UniProtKB/Swiss-Prot:Q3V2A7

    Gene LinkOut

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