Hbb-bt hemoglobin, beta adult t chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hbb-btprovided by MGI
Official Full Name: hemoglobin, beta adult t chainprovided by MGI
Primary source: MGI:MGI:5474850
See related: Ensembl:ENSMUSG00000073940 AllianceGenome:MGI:5474850
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Beta-t
Summary: This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a "single" haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a "diffuse" haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta t adult gene found in the "single" haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the "single" haplotype, while the "diffuse" haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]
Expression: Biased expression in spleen adult (RPKM 21891.7), heart adult (RPKM 7869.6) and 3 other tissues See more
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Genomic context

Location:: 7 E3; 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (103461731..103463130, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (103812524..103813923, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI747626 (e-PCR)
- UniSTS:208168

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516684

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:531320

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:525965

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516509

AI036344 (e-PCR)
- UniSTS:165546

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:516561

Hbb-b2 (e-PCR), detects polymorphism
- UniSTS:516562

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:259550

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to haptoglobin binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to haptoglobin binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables hemoglobin alpha binding	IBA Inferred from Biological aspect of Ancestor more info
enables hemoglobin alpha binding	ISO Inferred from Sequence Orthology more info
enables hemoglobin beta binding	ISO Inferred from Sequence Orthology more info
enables hemoglobin binding	ISO Inferred from Sequence Orthology more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to oxygen binding	ISO Inferred from Sequence Orthology more info
enables oxygen binding	ISO Inferred from Sequence Orthology more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of haptoglobin-hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of haptoglobin-hemoglobin complex	ISO Inferred from Sequence Orthology more info
part_of hemoglobin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of hemoglobin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hemoglobin, beta adult t chain

Names: beta t

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.