atad-3 ATPase family AAA domain-containing protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atad-3
Official Full Name: ATPase family AAA domain-containing protein 3
Primary source: WormBase:WBGene00010015
Locus tag: CELE_F54B3.3
See related: AllianceGenome:WB:WBGene00010015
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in mitochondrion organization. Located in mitochondrion. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Orthologous to several human genes including ATAD3A (ATPase family AAA domain containing 3A) and ATAD3B (ATPase family AAA domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See atad-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (10248991..10251165)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATAD-3 modulates mitochondrial iron and heme homeostasis.
Title: Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F54B3.3 (e-PCR)
- UniSTS:321504

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATPase family AAA domain-containing protein 3

NP_496210.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10248991..10251165

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063809.9 → NP_496210.2 ATPase family AAA domain-containing protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496210.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20748

Conserved Domains (3) summary

smart00382
Location:343 → 473

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:345 → 472

AAA; ATPase family associated with various cellular activities (AAA)

pfam12037
Location:38 → 283

DUF3523; Domain of unknown function (DUF3523)