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    ceh-22 Homeobox domain-containing protein;Homeobox protein ceh-22 [ Caenorhabditis elegans ]

    Gene ID: 179485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-22
    Official Full Name
    Homeobox domain-containing protein;Homeobox protein ceh-22
    Primary source
    WormBase:WBGene00000445
    Locus tag
    CELE_F29F11.5
    See related
    AllianceGenome:WB:WBGene00000445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including chordate pharyngeal muscle development; gonad morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including G1; gonad; neurons; pharynx; and ventral nerve cord. Used to study cancer. Orthologous to several human genes including NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-22 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10671918..10675769)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene TWiK family of potassium channels protein 12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple enhancers contribute to expression of the NK-2 homeobox gene ceh-22 in C. elegans pharyngeal muscle. Kuchenthal CA, et al. Genesis, 2001 Dec. PMID 11783006
    2. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Berger MF, et al. Nat Biotechnol, 2006 Nov. PMID 16998473, Free PMC Article
    3. Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Lam N, et al. Curr Biol, 2006 Feb 7. PMID 16461282, Free PMC Article
    4. Development of Caenorhabditis elegans pharynx, with emphasis on its nervous system. Pilon M, et al. Acta Pharmacol Sin, 2005 Apr. PMID 15780187
    5. pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus. Mörck C, et al. Dev Biol, 2004 Aug 15. PMID 15282157

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HTZ-1 and MYS-1 repress ceh-22 when UTX-1 removes its silencing mark, H3K27 methylation on the ceh-22 locus, thereby maintaining the fates of SGCs.
      Title: HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
    2. Results suggest that pan-pharyngeal Forkhead factor PHA-4 directly initiates homeobox gene ceh-22 expression through the oligonucleotide de209.
      Title: An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the Forkhead factor PHA-4.
    3. CEH-22/Nkx2.5 homeodomain transcription factor is a key regulator of distal tip cell specification.
      Title: Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell fate specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chordate pharyngeal muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein;Homeobox protein ceh-22
    NP_001076742.1
    • Confirmed by transcript evidence
    NP_001076743.1
    • Confirmed by transcript evidence
    NP_001076744.1
    • Partially confirmed by transcript evidence
    NP_001343841.1
    • Partially confirmed by transcript evidence
    NP_001343842.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10671918..10675769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083273.4 → NP_001076742.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076742.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1EHR3, A1EHR4, P41936, Q19908
      Conserved Domains (1) summary
      pfam00046
      Location:196 → 245
      Homeobox; Homeobox domain

    2. NM_001356738.3 → NP_001343841.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1EHR3, A1EHR4, P41936, Q19908
      UniProtKB/TrEMBL
      A0A2C9C3N2
      Conserved Domains (1) summary
      pfam00046
      Location:229 → 279
      Homeobox; Homeobox domain

    3. NM_001083275.4 → NP_001076744.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076744.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1EHR3, A1EHR4, P41936, Q19908
      Conserved Domains (1) summary
      pfam00046
      Location:133 → 182
      Homeobox; Homeobox domain

    4. NM_001356739.4 → NP_001343842.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C312
      Conserved Domains (1) summary
      pfam00046
      Location:110 → 160
      Homeobox; Homeobox domain

    5. NM_001083274.3 → NP_001076743.1  Homeobox protein ceh-22 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076743.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41936
      Conserved Domains (1) summary
      pfam00046
      Location:65 → 114
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

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