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    flp-1 SQPNFLRF-amide [ Caenorhabditis elegans ]

    Gene ID: 177737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-1
    Official Full Name
    SQPNFLRF-amide
    Primary source
    WormBase:WBGene00001444
    Locus tag
    CELE_F23B2.5
    See related
    AllianceGenome:WB:WBGene00001444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables neuropeptide receptor binding activity. Involved in several processes, including mechanosensory behavior; neuropeptide signaling pathway; and response to serotonin. Predicted to be located in extracellular region. Is expressed in nerve ring and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (9144705..9146128)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport protein 122 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4 Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle. Bowman JW, et al. Int J Parasitol, 2002 Dec 19. PMID 12464423
    2. KSAYMRFamide: a novel FMRFamide-related heptapeptide from the free-living nematode, Panagrellus redivivus, which is myoactive in the parasitic nematode, Ascaris suum. Maule AG, et al. Biochem Biophys Res Commun, 1994 Apr 29. PMID 8179635
    3. The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans. Rosoff ML, et al. Peptides, 1993 Mar-Apr. PMID 8483810
    4. Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network. Oranth A, et al. Neuron, 2018 Dec 19. PMID 30392795
    5. Identification of a platyhelminth neuropeptide receptor. Omar HH, et al. Int J Parasitol, 2007 Jun. PMID 17362965

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
      Title: Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
    2. Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.
      Title: Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables neuropeptide receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to serotonin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SQPNFLRF-amide
    NP_501592.1
    • Confirmed by transcript evidence
    NP_872077.1
    • Confirmed by transcript evidence
    NP_872078.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9144705..9146128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069191.8 → NP_501592.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855, Q7JKL0, Q8I122

    2. NM_182277.9 → NP_872077.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855

    3. NM_182278.7 → NP_872078.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41855.1

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