kin-30 Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: kin-30
Official Full Name: Protein kinase domain-containing protein
Primary source: WormBase:WBGene00002211
Locus tag: CELE_M01B2.1
See related: AllianceGenome:WB:WBGene00002211
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; gastrointestinal system cancer (multiple); germ cell cancer (multiple); hematologic cancer (multiple); and infantile myofibromatosis. Orthologous to several human genes including KIT (KIT proto-oncogene, receptor tyrosine kinase); FLT3 (fms related receptor tyrosine kinase 3); and PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

NP_506771.3

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