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    pph-4.1 Serine/threonine-protein phosphatase 4 catalytic subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 176657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pph-4.1
    Official Full Name
    Serine/threonine-protein phosphatase 4 catalytic subunit 1
    Primary source
    WormBase:WBGene00004085
    Locus tag
    CELE_Y75B8A.30
    See related
    AllianceGenome:WB:WBGene00004085
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in chiasma assembly; embryo development; and regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. Located in centrosome and cytoplasm. Orthologous to human PPP4C (protein phosphatase 4 catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pph-4.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (12345323..12351336, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene BZIP domain-containing protein Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein Neighboring gene FAM172 family protein homolog Y75B8A.31 Neighboring gene BZIP domain-containing protein Neighboring gene Serpentine receptor class gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age. Sato-Carlton A, et al. PLoS Genet, 2014 Oct. PMID 25340746, Free PMC Article
    2. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. Peters N, et al. J Cell Sci, 2010 Mar 1. PMID 20144993, Free PMC Article
    3. Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. Sumiyoshi E, et al. J Cell Sci, 2002 Apr 1. PMID 11896188
    4. Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity. Guo H, et al. Elife, 2022 Jun 27. PMID 35758641, Free PMC Article
    5. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Han X, et al. Genetics, 2009 Mar. PMID 19087961, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that in Caenorhabditis elegans, PPH-4.1, is required independently to carry out four separate functions involving meiotic chromosome dynamics
      Title: Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 4 catalytic subunit 1
    NP_499603.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12345323..12351336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067202.6 → NP_499603.1  Serine/threonine-protein phosphatase 4 catalytic subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q966Q4, Q9XW79
      Conserved Domains (2) summary
      PTZ00239
      Location:31 → 333
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:31 → 316
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW79.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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