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    fkb-4 peptidylprolyl isomerase [ Caenorhabditis elegans ]

    Gene ID: 179752, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fkb-4
    Official Full Name
    peptidylprolyl isomerase
    Primary source
    WormBase:WBGene00001429
    Locus tag
    CELE_ZC455.10
    See related
    AllianceGenome:WB:WBGene00001429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 11. Orthologous to human FKBP10 (FKBP prolyl isomerase 10) and FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fkb-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (12785153..12787126, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DH domain-containing protein;LIM domain protein;RING-type domain-containing protein;UDENN domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene Serpentine Receptor, class E (Epsilon) Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Serpentine Receptor, class BC (Class B-like)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality and associate extracellular matrix defects in the nematode Caenorhabditis elegans. Winter AD, et al. J Biol Chem, 2007 Apr 27. PMID 17339317
    2. Sequence diversification of the FK506-binding proteins in several different genomes. Galat A. Eur J Biochem, 2000 Aug. PMID 10931176
    3. DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs. Yu H, et al. J Mol Biol, 2001 Dec 14. PMID 11743719
    4. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article
    5. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peptidylprolyl isomerase
    NP_506197.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12785153..12787126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073796.6 → NP_506197.1  peptidylprolyl isomerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23338
      Conserved Domains (1) summary
      pfam00254
      Location:161 → 250
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version

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