mre-11 Double-strand break repair protein mre-11 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mre-11
Official Full Name: Double-strand break repair protein mre-11
Primary source: WormBase:WBGene00003405
Locus tag: CELE_ZC302.1
See related: AllianceGenome:WB:WBGene00003405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA metabolic process and mitotic DNA damage checkpoint signaling. Located in nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mre-11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (10733931..10736671, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization.
Title: Recruitment of MRE-11 to complex DNA damage is modulated by meiosis-specific chromosome organization.
A novel role for MRE-11 in the resection of double strand breaks in middle meiotic prophase I and in blocking nonhomologous end joining.
Title: Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC302.1 (e-PCR)
- UniSTS:310352

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA endodeoxyribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic DNA double-strand break formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Mre11 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mre11 complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Double-strand break repair protein mre-11

NP_505736.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10733931..10736671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073335.8 → NP_505736.2 Double-strand break repair protein mre-11 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505736.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23255

Conserved Domains (3) summary

TIGR00583
Location:63 → 472

mre11; DNA repair protein (mre11)

cd00840
Location:67 → 335

MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain

pfam04152
Location:358 → 533

Mre11_DNA_bind; Mre11 DNA-binding presumed domain