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    mod-1 Serotonin-gated chloride channel mod-1 [ Caenorhabditis elegans ]

    Gene ID: 179269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mod-1
    Official Full Name
    Serotonin-gated chloride channel mod-1
    Primary source
    WormBase:WBGene00003386
    Locus tag
    CELE_K06C4.6
    See related
    AllianceGenome:WB:WBGene00003386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; chloride transmembrane transport; and locomotory exploration behavior. Located in neuronal cell body and plasma membrane. Is expressed in body wall musculature and neurons. Used to study cocaine abuse. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mod-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (8909704..8914040, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit. Aprison EZ, et al. Curr Biol, 2019 Dec 2. PMID 31708394, Free PMC Article
    2. MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Ranganathan R, et al. Nature, 2000 Nov 23. PMID 11100728
    3. Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans. Mori H, et al. PLoS One, 2019. PMID 31800640, Free PMC Article
    4. PharmacoGenetic targeting of a C. elegans essential neuron provides an in vivo screening for novel modulators of nematode ion channel function. Calahorro F, et al. Pestic Biochem Physiol, 2022 Aug. PMID 35973757
    5. The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy. Rodriguez Araujo N, et al. J Biol Chem, 2022 Sep. PMID 35952761, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mod-1 is expressed in the neurons and muscles that directly control locomotion.
      Title: Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
    2. Mod-1 modulates interneuronal signaling to stimulate reversal and backward locomotion.
      Title: Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.
    3. the central ring of charge formed by the M2 segments of the 5-hydroxytryptamine-gated chloride channel MOD-1 has a critical role in determining anion/cation permeability
      Title: Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic anion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serotonin-gated chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in serotonin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serotonin-gated chloride channel mod-1
    NP_001024034.1
    • Confirmed by transcript evidence
    NP_001024035.1
    • Partially confirmed by transcript evidence
    NP_741580.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8909704..8914040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171495.6 → NP_741580.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H2L0B8, Q8MPU3, Q9GQ00, Q9GYH1
      Conserved Domains (3) summary
      TIGR00860
      Location:7 → 479
      LIC; Cation transporter family protein
      pfam02931
      Location:34 → 239
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 476
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001028863.5 → NP_001024034.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPU3
      Conserved Domains (3) summary
      TIGR00860
      Location:7 → 465
      LIC; Cation transporter family protein
      pfam02931
      Location:34 → 239
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 462
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001028864.4 → NP_001024035.1  Serotonin-gated chloride channel mod-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0B8
      Conserved Domains (2) summary
      pfam02931
      Location:34 → 239
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:247 → 327
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GQ00.1

    Gene LinkOut

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