hlh-16 BHLH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hlh-16
Official Full Name: BHLH domain-containing protein
Primary source: WormBase:WBGene00001960
Locus tag: CELE_DY3.3
See related: AllianceGenome:WB:WBGene00001960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Involved in neuron projection development. Predicted to be active in nucleus. Is expressed in ABplpapaaa; ABplpapaap; ABprpapaaa; ABprpapaap; and ventral ganglion. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hlh-16 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (8766840..8768082, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports that the Beta3/Olig-type bHLH transcription factor hlh-16 is left/right asymmetrically expressed in several distinct, otherwise bilaterally symmetric interneuron and motoneuron pairs that are part of a known navigation circuit.
Title: Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DY3.3 (e-PCR)
- UniSTS:318043

DY3.4 (e-PCR)
- UniSTS:306402

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BHLH domain-containing protein

NP_492372.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8766840..8768082 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059971.3 → NP_492372.2 BHLH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492372.2

Status: REVIEWED

UniProtKB/TrEMBL

O45320

Conserved Domains (1) summary

cd11390
Location:42 → 96

bHLH_TS; tissue specific basic helix-loop-helix (bHLH-TS) domain family