ubc-21 Ubiquitin-conjugating enzyme E2 21 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ubc-21
Official Full Name: Ubiquitin-conjugating enzyme E2 21
Primary source: WormBase:WBGene00006716
Locus tag: CELE_C06E2.3
See related: AllianceGenome:WB:WBGene00006716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Orthologous to human UBE2K (ubiquitin conjugating enzyme E2 K). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ubc-21 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (8869625..8871901)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C06E2.7 (e-PCR)
- UniSTS:317835

C06E2.3 (e-PCR)
- UniSTS:319992

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in protein modification by small protein conjugation	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ubiquitin-conjugating enzyme E2 21

NP_509502.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

8869625..8871901

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077101.4 → NP_509502.3 Ubiquitin-conjugating enzyme E2 21 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509502.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P52484

Conserved Domains (3) summary

COG5078
Location:15 → 167

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cd14313
Location:178 → 213

UBA_II_E2_UBE2K_like; UBA domain found in vertebrate ubiquitin-conjugating enzyme E2 K (UBE2K), Drosophila melanogaster ubiquitin-conjugating enzyme E2-22 kDa (UbcD4) and similar proteins

pfam00179
Location:25 → 163

UQ_con; Ubiquitin-conjugating enzyme