unc-62 Homeobox domain-containing protein;Homeobox protein unc-62 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-62
Official Full Name: Homeobox domain-containing protein;Homeobox protein unc-62
Primary source: WormBase:WBGene00006796
Locus tag: CELE_T28F12.2
See related: AllianceGenome:WB:WBGene00006796
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification; muscle cell differentiation; and regulation of gene expression. Acts upstream of or within lipid homeostasis. Located in chromatin and nucleus. Is expressed in several structures, including body wall musculature; hypodermis; neurons; reproductive system; and vulval precursor cell. Used to study leukemia and restless legs syndrome. Human ortholog(s) of this gene implicated in alcohol dependence; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft (multiple). Orthologous to several human genes including MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-62 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (4497463..4511447)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
Title: Synergistic roles of homeodomain proteins UNC-62 homothorax and MLS-2 HMX/NKX in the specification of olfactory neurons in Caenorhabditis elegans.
Different Meis/UNC-62 isoforms act through specific regions of the unc-55 promoter. UNC-62 isoforms differentially regulate the mRNA and protein expression of UNC-55.
Title: Meis/UNC-62 isoform dependent regulation of CoupTF-II/UNC-55 and GABAergic motor neuron subtype differentiation.
These results illustrate how unc-62 regulation of intestinal gene expression is responsible for limiting lifespan during the normal aging process.
Title: Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.
UNC-62 plays essential roles in regulating cell fate specification & differentiation in the mesodermal M lineage. UNC-62 functions together with CEH-20 in regulating these processes.
Title: Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development.
Functions independently of lin-39 in vulva development.
Title: The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS5-138 (e-PCR)
- UniSTS:242297

T28F12.2a (e-PCR)
- UniSTS:321700

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in eye development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mesodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox domain-containing protein;Homeobox protein unc-62

NP_001024169.1

Confirmed by transcript evidence

NP_001024170.1

Confirmed by transcript evidence

NP_001024173.1

Confirmed by transcript evidence

NP_001024175.1

Confirmed by transcript evidence

NP_001300207.1

Confirmed by transcript evidence

NP_001367923.1

Confirmed by transcript evidence

NP_001367924.1

Confirmed by transcript evidence

NP_001370772.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4497463..4511447

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380635.2 → NP_001367923.1 Homeobox protein unc-62 [Caenorhabditis elegans]

Status: REVIEWED
NM_001028998.5 → NP_001024169.1 Homeobox protein unc-62 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024169.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5TKQ8, Q8MXU6, Q8MXU7, Q8WRQ5, Q8WRQ6, Q9N5D5, Q9N5D6

Conserved Domains (2) summary

pfam05920
Location:410 → 449

Homeobox_KN; Homeobox KN domain

pfam16493
Location:133 → 218

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001380634.1 → NP_001367924.1 Homeobox protein unc-62 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

pfam05920
Location:406 → 445

Homeobox_KN; Homeobox KN domain

pfam16493
Location:133 → 219

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001383298.1 → NP_001370772.1 Homeobox protein unc-62 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam05920
Location:3 → 38

Homeobox_KN; Homeobox KN domain
NM_001028999.5 → NP_001024170.1 Homeobox protein unc-62 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024170.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N5D6

Conserved Domains (2) summary

pfam05920
Location:373 → 412

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 181

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001029002.4 → NP_001024173.1 Homeobox protein unc-62 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024173.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N5D6

Conserved Domains (2) summary

pfam05920
Location:369 → 408

Homeobox_KN; Homeobox KN domain

pfam16493
Location:96 → 181

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001313278.3 → NP_001300207.1 Homeobox domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASC5

Conserved Domains (2) summary

pfam05920
Location:332 → 371

Homeobox_KN; Homeobox KN domain

pfam16493
Location:59 → 145

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
NM_001029004.5 → NP_001024175.1 Homeobox protein unc-62 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024175.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N5D6

Conserved Domains (2) summary

pfam05920
Location:336 → 375

Homeobox_KN; Homeobox KN domain

pfam16493
Location:59 → 144

Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1