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    ncam-1 NCAM (neural cell adhesion molecule) homolog [ Caenorhabditis elegans ]

    Gene ID: 180418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ncam-1
    Official Full Name
    NCAM (neural cell adhesion molecule) homolog
    Primary source
    WormBase:WBGene00017184
    Locus tag
    CELE_F02G3.1
    See related
    AllianceGenome:WB:WBGene00017184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in axon guidance; dendrite self-avoidance; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in cytoplasm and membrane. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including GLR; germ line; neurons; somatic nervous system; and spermatheca. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1) and NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ncam-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (691913..703040)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene Lipase_GDSL domain-containing protein Neighboring gene Tumor protein p53-inducible protein 11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inward rectifier potassium channel irk-1 Neighboring gene Uncharacterized protein Neighboring gene E3 ubiquitin-protein ligase CBL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conserved role of neural cell adhesion molecule-1 in memory. Vukojevic V, et al. Transl Psychiatry, 2020 Jul 6. PMID 32632143, Free PMC Article
    2. Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans. Nordquist SK, et al. G3 (Bethesda), 2018 Mar 2. PMID 29367452, Free PMC Article
    3. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
    4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary conserved role of neural cell adhesion molecule-1 in memory.
      Title: Evolutionary conserved role of neural cell adhesion molecule-1 in memory.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dendrite self-avoidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NCAM (neural cell adhesion molecule) homolog
    NP_741707.3
    • Product from WormBase gene class ncam;
      Confirmed by transcript evidence
    NP_741708.1
    • Product from WormBase gene class ncam;
      Confirmed by transcript evidence
    NP_741709.1
    • Product from WormBase gene class ncam;
      Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      691913..703040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171615.7 → NP_741707.3  NCAM (neural cell adhesion molecule) homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741707.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19128, Q8WR46
      Conserved Domains (6) summary
      cd00096
      Location:42 → 113
      Ig; Immunoglobulin domain
      smart00408
      Location:229 → 293
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:37 → 115
      IG; Immunoglobulin
      smart00410
      Location:229 → 303
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 674
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:133 → 195
      Ig; Immunoglobulin domain

    2. NM_171616.5 → NP_741708.1  NCAM (neural cell adhesion molecule) homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741708.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3E5
      Conserved Domains (6) summary
      cd00096
      Location:42 → 113
      Ig; Immunoglobulin domain
      smart00408
      Location:229 → 293
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:37 → 115
      IG; Immunoglobulin
      smart00410
      Location:229 → 303
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 674
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:133 → 195
      Ig; Immunoglobulin domain

    3. NM_171617.5 → NP_741709.1  NCAM (neural cell adhesion molecule) homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQ86
      Conserved Domains (6) summary
      cd00096
      Location:69 → 140
      Ig; Immunoglobulin domain
      smart00408
      Location:256 → 320
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:64 → 142
      IG; Immunoglobulin
      smart00410
      Location:256 → 330
      IG_like; Immunoglobulin like
      cd00063
      Location:652 → 701
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:160 → 222
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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