sdf-9 Protein sdf-9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sdf-9
Official Full Name: Protein sdf-9
Primary source: WormBase:WBGene00004748
Locus tag: CELE_Y44A6D.4
See related: AllianceGenome:WB:WBGene00004748
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Is expressed in head. Human ortholog(s) of this gene implicated in coronary artery disease; essential hypertension; and type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sdf-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (20798218..20801207)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genetic and molecular analyses; SDF-9 involved in the regulation of dauer larva formation
Title: SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y44A6D.4 (e-PCR)
- UniSTS:313312

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein tyrosine phosphatase activity	IKR Inferred from Key Residues more info	PubMed

Process	Evidence Code	Pubs
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein sdf-9

NP_508013.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20798218..20801207

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075612.4 → NP_508013.2 Protein sdf-9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508013.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGA9

Conserved Domains (2) summary

smart00194
Location:7 → 283

PTPc; Protein tyrosine phosphatase, catalytic domain

cl21483
Location:34 → 283

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...