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    uev-3 UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2 [ Caenorhabditis elegans ]

    Gene ID: 185003, updated on 9-Dec-2024

    Summary

    Official Symbol
    uev-3
    Official Full Name
    UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2
    Primary source
    WormBase:WBGene00006732
    Locus tag
    CELE_F26H9.7
    See related
    AllianceGenome:WB:WBGene00006732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be located in several cellular components, including axon; cilium; and dendrite. Predicted to be active in nucleus. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See uev-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9310319..9312642)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Neighboring gene small monomeric GTPase Neighboring gene putative phosphoserine aminotransferase Neighboring gene UDP-glucose:Glycoprotein Glucosyltransferase Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in protein polyubiquitination  
    Component Evidence Code Pubs
    located_in axon  
    located_in cell projection  
    located_in cilium  
    located_in cytoplasm  
    located_in dendrite  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    UBC core domain-containing protein;Ubiquitin-conjugating enzyme E2
    NP_001361859.1
    • Confirmed by transcript evidence
    NP_001362168.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9310319..9312642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375060.3NP_001362168.1  UBC core domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91853
      UniProtKB/TrEMBL
      A0A5K1ICF0
      Conserved Domains (2) summary
      PHA03247
      Location:973
      PHA03247; large tegument protein UL36; Provisional
      cl00154
      Location:147281
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001375057.2NP_001361859.1  Ubiquitin-conjugating enzyme E2 variant 3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91853
      Conserved Domains (2) summary
      PHA03247
      Location:973
      PHA03247; large tegument protein UL36; Provisional
      cl00154
      Location:185319
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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