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    eak-6 Tyrosine-protein phosphatase non-receptor type eak-6 [ Caenorhabditis elegans ]

    Gene ID: 184324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eak-6
    Official Full Name
    Tyrosine-protein phosphatase non-receptor type eak-6
    Primary source
    WormBase:WBGene00008663
    Locus tag
    CELE_F10G8.4
    See related
    AllianceGenome:WB:WBGene00008663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Is expressed in XXXL and XXXR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eak-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (10023798..10025838)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein-tyrosine phosphatase Neighboring gene Protein kinase domain-containing protein Neighboring gene mRNA export factor rae-1 Neighboring gene ERCC1-like central domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. Hu PJ, et al. PLoS Genet, 2006 Jul. PMID 16839187, Free PMC Article
    2. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dumas KJ, et al. Dev Biol, 2010 Apr 15. PMID 20178781, Free PMC Article
    3. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Zhang Y, et al. Dev Biol, 2008 Mar 15. PMID 18241854, Free PMC Article
    4. EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Alam H, et al. Cell Metab, 2010 Jul 7. PMID 20620993, Free PMC Article
    5. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein phosphatase non-receptor type eak-6
    NP_001122448.1
    • Confirmed by transcript evidence
    NP_001122449.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10023798..10025838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128976.3 → NP_001122448.1  Tyrosine-protein phosphatase non-receptor type eak-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGU2
      Conserved Domains (2) summary
      smart00194
      Location:36 → 308
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:66 → 307
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001128977.1 → NP_001122449.1  Tyrosine-protein phosphatase non-receptor type eak-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122449.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEU5, G5EGU2
      Conserved Domains (2) summary
      smart00194
      Location:36 → 308
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:66 → 307
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EGU2.1

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